At AstraZeneca, we win through science, it’s at the heart of our every success. That science is only possible when we all work together – we’ll always make sure you’re clear about how your role is connected to our wider mission to really show what science can do!
 

We are seeking an Associate Principal Scientist/Associate Director to join Integrated Bioanalysis organization to support biomarker discovery and validation as well as pharmacokinetic/toxicokinetic assessments for critical projects within AstraZeneca portfolio employing mass spectrometry-based approaches within the context of non-clinical and clinical studies.

Your primary responsibilities will include:

• Apply state-of-the-art mass spectrometry instrumentation to address sophisticated bioanalytical challenges related to drug discovery and development

• Development, validation/qualification of state-of-the-art mass spectrometry assays in support of pharmacokinetic, toxicokinetic, pharmacodynamic, mechanistic, safety, prognostic and diagnostic biomarkers in variety of biological matrices

• Employ a metabolomic/proteomics discovery platform to enable discovery and validation of metabolomic/lipidomic/proteomics biomarkers

• Sample analysis for exploratory, GLP and clinical studies using automated and manual sample extraction platforms

• Perform data analysis on acquired datasets, collaborate with pharmacologists, statisticians, data scientists across global AstraZeneca teams

• Serve as functional representative/expert on multidisciplinary project teams

• Adhere to established Standard Operating Procedures, industry practice and regulatory guidance as appropriate

• Contribute to validation/qualification protocols and reports, bioanalytical reports, clinical study reports, etc., as appropriate

• Demonstrate competency in troubleshooting, optimization and implementation of challenging and innovative LC-MS/MS assays

Essential Requirements:

• PhD in Chemistry, Biochemistry or Pharmaceutical Sciences

• 5-10 years of postdoctoral or equivalent experience

• Pharmaceutical/biotech Industry experience

• Some background in analytical (bio)chemistry with emphasis on mass spectrometry applications in at least one of the following: PK of biologics (preferably ADCs), biomarker quantification, metabolomics, lipidomics or proteomics

• Familiarity with high resolution (HRMS, ToF or Orbitrap) and QqQ instruments;

• Hands-on experience with chromatographic separation, characterization and quantification of various analytes by LCMS.

• Proficiency with mass spectrometry software, data analysis software (Spotfire, MATLAB, R, JMP, etc.) word processing, and graphical computer programs

• Significant experience in method development, troubleshooting and complex OMICs data analysis

• Experience serving as functional representative on multidisciplinary project teams with demonstrated ability to communicate complex data effectively to diverse audiences

• Strong publication/presentation record in analytical (bio)chemistry, bioanalysis, metabolomics/proteomics, or biomarker discovery

• Excellent organizational,  documentation and technical writing skills

• Excellent command of English (written and oral)

• Strong communication and interpersonal skills

• Experience mentoring/supervising more junior staff

Desirable Requirements

• Experience with automated/semi-automated sample preparation

• Background in bioinformatics/statistical analysis of -omics datasets

• Familiarity with chromatographic assay validation guidelines, GLP regulations and fit-for-purpose biomarker validation principles

• Familiarity with gas chromatography (GC-MS), Capillary Electrophoresis (CE) or ion mobility (IMS)

• Experience in bioanalysis of antibody-drug conjugates

• Familiarity with drug metabolite identification and profiling studies

• Small-molecule mass spectrometry experience

• Expertise in bioanalysis of antibody-drug conjugates

Familiarity with drug metabolite identification and profiling studies

Benefits:

AstraZeneca is a leading company in the healthcare industry, with a mission to enrich the lives of others. It’s our business to support healthy living, not only for our patients, but also for our employees. Our benefits program is flexible enough to meet employees’ varying needs, offers valuable choices, and is highly competitive.

Why AstraZeneca?

At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognising their potential. Join us on our journey of building a new kind of organisation to reset expectations of what a bio-pharmaceutical company can be. This means we’re opening new ways to work, pioneering cutting edge methods and bringing unexpected teams together.

Come and join our journey -  Apply today!

Where can I find out more?

Our Social Media, Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/

Follow AstraZeneca on Facebook https://www.facebook.com/astrazenecacareers/

Follow AstraZeneca on Instagram https://www.instagram.com/astrazeneca_careers/?hl=en

Date Posted

Closing Date

AstraZeneca embraces diversity and equality of opportunity.  We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills.  We believe that the more inclusive we are, the better our work will be.  We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics.  We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.