Associate Principal Scientist / Senior Research Scientist- HTS
Location: Alderley Park, Cheshire with relocation to Cambridge, UK
Competitive salary with excellent benefits
 

Diverse Minds. Go further with bold new opportunities Collaborate with diverse minds

Collaborate in an inclusive environment, a place full of bold new opportunities. And in return… we’re looking for people who are open and respectful, ambitious and driven.

Who you are

You will be an experienced drug discovery scientist with knowledge of screening and a passion for data analysis?

Who we are

We are looking to recruit an Associate Principal Scientist or Senior Research Scientist with a keen interest in data analysis to join our Global High Throughput Screening (HTS) Centre in Alderley Park, prior to relocation to a new, state-of-the-art R&D centre in Cambridge. This is a great opportunity to lead and champion data interpretation as part of a team utilising world-class science and technology to deliver the most innovative tools for drug discovery.

HTS is the only department within our world-leading pharmaceutical business that focuses unequivocally on hit identification. This means you'll get unrivalled exposure to the drug discovery process, working on multiple projects across therapeutic areas in a culture that fosters collaboration and open innovation - find out more at http://openinnovation.astrazeneca.com/

Our HTS centre supports design of screening cascades in discovery programmes, uses cutting-edge assay technologies to generate high-quality screening data and delivers robust data packages to pursue tractable hit series. This role will encompass all these elements and more providing an opportunity for you to share and apply your experience whilst accessing development support to build upon it.

What you'll do
 

Primarily you will have specific accountability for overseeing and developing the analysis methods employed to interrogate HTS data sets for identification of compounds of interest. In addition, as an experienced member you will support scientific development of the department across all areas and capitalise on publication and collaboration opportunities whilst mentoring less experienced scientists. In a lab-based capacity, you’ll be tasked with delivering excellence in data generation for cellular and biochemical targets. This incorporates aiding design of a project’s hit identification strategy and triage cascade, close cooperation with key groups in assay development and reagent supply and prosecution of the screening campaign.
 

Location
This role will initially be based at Alderley Park, Cheshire prior to the group relocating to Cambridge so you must be committed to moving with this role.
 

Work with curious minds in an inclusive culture

Seamlessly come together in our inclusive environment. Here all doors are open, and every voice is heard. From working side-by-side with academia to innovating with biotech – we are forever expanding our horizons.

By sharing and increasing our knowledge we are empowered to be the best we can be and accelerate progress.

Essential Criteria

• BSc/PhD in a relevant discipline
• Solid understanding of data analysis principles as applied to large data sets and familiarity with data analysis software packages
• Significant experience in the pharmaceutical industry and drug discovery process
• Demonstrable experience in cell and/or biochemical screening approaches and ability to troubleshoot problems
• Ability to drive the practical application of new assay approaches to screening and drug discovery science
• Agile at learning new concepts and adapting to new technologies, projects and collaborators
• A history of scientific publication/presentation

Desirable Criteria

• Understanding of the analysis and interpretation of screening data
• Experience of applying high volume/complexity data generation methods to drug discovery projects
• Familiarity with coding languages such as R/Python etc
• Experience of small molecule screening and/or fragment-based screening.
• Experience in several cellular and biochemical screening technologies
• Assay Development, cascade design and drug discovery project team experience
• Familiarity with laboratory automation
• An advanced degree in a related field and/ or professional certification

Make a more meaningful impact to patients’ lives around the globe

At AstraZeneca we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learning, growth and development.

So, what’s next?

Complete your application before the below closing date.

This role is open from 2 June 2021 and welcome with your application no later than 16 June 2021

Where can I find out more?

Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/

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Date Posted

Closing Date

AstraZeneca embraces diversity and equality of opportunity.  We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills.  We believe that the more inclusive we are, the better our work will be.  We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics.  We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.