Associate Principal Scientist in Immuno-Oncology (IO)

Permanent Opportunity

Location: Cambridge, UK

Do you have expertise in, and a passion for immune-Oncology? Would you like to apply your expertise to impact the lives of patient’s living with cancer in a company that follows the science and turns ideas into life changing

medicines? Then AstraZeneca might be the one for you!

About AstraZeneca

AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development and commercialisation of prescription medicines for some of the world’s most serious diseases. But we’re more than one of the world’s leading pharmaceutical companies.

A place built on courage, curiosity and collaboration – we make bold decisions driven by patient outcomes. Empowered to lead at every level, free to ask questions and take smart risks that write the next chapter for our pipeline and Oncology team.

At AstraZeneca, we're proud to have a unique workplace culture that inspires innovation and collaboration. Here, employees are empowered to express diverse perspectives - and are made to feel valued, energised and rewarded for their ideas and creativity.

Site Description

Welcome to Granta Park Cambridge, one of over 400 sites here at AstraZeneca!

Providing a collaborative environment where everyone feels comfortable and able to be themselves is at the core of AstraZeneca’s priorities, it’s important to us that you bring your full self to work every day.

To help you maintain your best self, here’s a sneak peek into some of the things this site provides for you. Granta Park has a gym, nursery and central restaurant/coffee place as part of the science park facilities that are accessible to our staff. We also have our own bistro and deli in the AZ buildings. There are regular lunch & learn events and after work socials on the last Friday of every month. This is our biggest and most spacious lab site - come and join us!

Business area

In the Oncology Business Unit we relentlessly follow the science, challenging the status quo to deliver more effective treatments to patients in need. Our dedication means we purposefully push back the limits of knowledge to change the practice of medicine. To ensure no patient is left behind, no matter what stage of disease.

Fast-paced and ever-changing, it takes agility and responsiveness to stay committed in our pursuit of excellence. We work with focus and a sense of urgency to seek the unanswered questions – innovating, challenging accepted norms, quick decision-making and taking smart risks. A place of trust, it’s an opportunity to take accountability, be brave, speak up, step up and disrupt to change the game for Oncology, now and in the future. Be a part of improving lives. This is the time to join the team who is confident that cures for cancer are within our grasp.

AstraZeneca’s vision in Oncology is to push the boundaries of science to change the practice of medicine, transform the lives of patients living with cancer, and to ultimately eliminate cancer as a cause of death. A broad pipeline of next-generation medicines is focused principally on four disease areas - breast, ovarian, lung and haematological cancers.

We seek a highly motivated Associate Principal Scientist in Immuno-Oncology (IO) with deep scientific and technical expertise in tumor IO and a track record of successful leadership of cross-functional project teams to join our team in Cambridge, UK. As a subject matter specialist and Project Leader within the Clinical IO Bioscience team, you will play a pivotal role in progressing the next generation of innovative IO therapies, and in deepening our understanding of cancer immunology.

Main Duties and Responsibilities

Working in this scientific leadership role within the Clinical IO Bioscience team, you will apply your technical and scientific skills to improving successful clinical translation and life-cycle management of clinical stage assets. As the bioscience lead on one or more cross-functional project teams you will be responsible for developing and delivering relevant pharmacology and biomarker strategy, gain a deeper understanding of mechanism and inform various aspects of clinical development. Necessarily, you will stay up to date with the latest discoveries in tumor immunology, share your expertise both within and beyond the bioscience group, publish peer reviewed articles on your research, develop and lead external collaborations and contribute to the scientific and strategic direction of the department.

You will primarily matrix manage the project bioscience team, providing expert advice and mentorship, interpreting complex data and making high level recommendations. You will apply your influencing, coaching and mentoring skills to ensure effective cross-functional working within teams. Necessarily, there will be a strong working relationship with colleagues in translational sciences and partner lines allied to delivering the pharmacology. There will also be some requirement to undertake focused laboratory based work to advance your projects / train staff, as appropriate.

Essential Requirements

• PhD (or equivalent) in a biological science with at least several years of research experience post-PhD in academia or industry
• Deep expertise in tumor microenvironmental biology, plus broad understanding and enthusiasm for tumor immunology and cancer therapies
• General knowledge of biologics drug development
• Track record of successful scientific leadership of cross-functional scientific project teams or an academic research group lead
• Technical expertise in preclinical models to enable successful clinical translation and biomarker profiling.
• Excellent scientific communication skills including both written reports (e.g. manuscripts) and oral presentations to broad and diverse audiences
• Willingness to undertake some hands-on laboratory based activities to achieve project deliverables and train, oversee, coach and mentor other colleagues working on the project.

Desirable Requirements

• Experience working in the field of IO drug discovery
• Authorship of patents, grants and/or publications in top-tier scientific journals
• Line management experience

Why AstraZeneca?

At AstraZeneca, we 're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration, and always committed to lifelong learning, growth and development. We’re on an exciting journey to pioneer the future of healthcare.

So, what’s next?

• Are you already imagining yourself joining our team? Good, because we can’t wait to hear from you.

Competitive salary and benefits package on offer.

The successful candidate will have access to a flexible employee benefits fund, including holiday purchase and flexible time off, pension contributions, Share Save Plans, A performance recognition scheme and a competitive, generous remuneration package.

Closing date: 14th September 2021

Where can I find out more?

Our Social Media, Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/

Follow AstraZeneca on Facebook https://www.facebook.com/astrazenecacareers/

Follow AstraZeneca on Instagram https://www.instagram.com/astrazeneca_careers/?hl=en

Date Posted

Closing Date

AstraZeneca embraces diversity and equality of opportunity.  We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills.  We believe that the more inclusive we are, the better our work will be.  We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics.  We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.