JOB TITLE: Associate Principal Specialist Physician – Early Oncology
Do you have expertise in, and passion for clinical drug development? Are you looking to work at the cutting-edge, where scientific innovations and an entrepreneurial spirit are the norm? Join the team at the heart of AstraZeneca dedicated to Oncology, committed to following the science.

About AstraZeneca
AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development and commercialisation of prescription medicines for some of the world’s most serious diseases. We are more than one of the world’s leading pharmaceutical companies.

Headquartered in Mississauga, Ontario, we’ve been recognized as one of Greater Toronto Area’s Top Employers for 7 straight years. Our collaborative work environment fosters knowledge-sharing, decision-making, and entrepreneurial thinking. Our employees have the opportunity to work across teams, functions, and even the globe. With a commitment to sustainability, we’re working towards making a meaningful impact where society needs it — health. We know the health of people, the planet and our business are interconnected, each impacting the others.

Oncology Research & Development
Our ambition is to eliminate cancer as a cause of death. It’s our big vision that unites and inspires us. With multiple indications and high-quality molecules at all stages of our innovative pipeline, we keep pushing forward. Focusing on cutting-edge science with the latest technology to achieve breakthroughs. AZ is a place built on courage, curiosity and collaboration – we make bold decisions driven by patient outcomes.

What you’ll do
As a Specialist Physician, you will provides medical advice within clinical research projects. You are a recognised expert in your own field and often first point of contact for related queries to seek solutions and to explain difficult concepts.

Other responsibilities include but are not limited to:
• Reviews literature and consults with internal experts to identify biological mechanisms underlying pathophysiology and/or potential drug effects
• Assists in the design and execution of studies to assess biological mechanisms such as preparing pharmacogenetics components of clinical study protocols
• Liaises with colleagues in Clinical Pharmacology to assist in the design and execution of Phase I Clinical trials to establish Proof of Principle and to support Proof of Concept
• Initiates and monitors epidemiological research done by external scientific groups and provides medical/physician expertise to epidemiology colleagues who are not physicians
• Acts as a regional technical expert supporting the delivery of strategic input within the area of Physicians and provides consultancy within area of specialism
• Responsible for the safety evaluation in the early clinical trials, as well as the pharmacodynamic evaluation of the early compounds
• Delivers pharmacogenetics contribution to Translational Science Plans and Clinical Development Plans
• Supervises volunteers participating in medical trials and reviews safety assessments
• Leads the development of setting statistical standards or techniques in order that the quality, efficiency or effectiveness of projects are improved for overall Group efficiency
• Accountable for specialized research to enhance the effectiveness of Biostatistics contributions to worldwide submissions across a range of products
• Provides highly experienced strategic input, statistical expertise, and leadership to project teams in the design and interpretation of clinical studies and programmes of studies
• Applies expert physician skills to support internal proposal development and external regulatory submissions
• Acts as a source of knowledge in area of expertise, defining and communicating important initiatives across departments and functions
• Contributes to establishing and implementing policies, procedures and objectives for own work or team area to ensure compliance with both internal and external regulations
• Provides professional expertise to optimally design, analyze and interpret epidemiological studies and perform in depth epidemiological literature reviews
• Responsible for the safety evaluation in early clinical trials, as well as the proper pharmacodynamic evaluation of the early compounds
• Promotes good physician practice and ensures adherence with relevant protocols
• Develops operational systems and research processes across area of responsibility to increase the effectiveness and efficiency of projects

Essential for the role

• MD degree in Medicine or equivalent international degree
• Board Certification is preferred in Oncology or Hem Onc
• Thorough knowledge of clinical study analysis and design in all phases of drug development, industry experience preferred
• Experience of modelling and simulation to improve execution of studies

Why AstraZeneca?
Here you’ll have the opportunity to make a meaningful difference to patients’ lives. With science at its heart, this is the place where breakthroughs born in the lab become transformative medicines – for the world’s most complex diseases. Answer unmet medical needs by pioneering the next wave of science, focusing on outcomes and shaping the patient ecosystem.

So, what’s next?
• Are you already imagining yourself joining our team? Good, because we can’t wait to hear from you!

Great People want to Work with us! Find out why:
• GTAA Top Employer Award for 7 years:https://reviews.canadastop100.com/top-employer-astrazeneca-canada
• Best Workplace Culture Award at the 2018 Canadian HR Awards:https://www.linkedin.com/pulse/thriving-best-workplace-culture-gena-restivo/
• Browse AstraZeneca's YouTube channel to find out more about us:https://www.youtube.com/user/astrazeneca

Date Posted

Closing Date

AstraZeneca embraces diversity and equality of opportunity.  We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills.  We believe that the more inclusive we are, the better our work will be.  We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics.  We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.