Cardiovascular Renal and Metabolism (CVRM) Research – Metabolism In Vitro Team

Cambridge

12 month Fixed Term Contract- Maternity cover

Salary Competitive

Are you a Scientist with clinical research experience in either cardiovascular, renal or metabolic disease? Would you like to make a difference where science meets the patient? Join us now to be part of the discovery and development of future treatments of Cardiovascular, Renal and Metabolic diseases!

At AstraZeneca we turn ideas into life changing medicines. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. This role will give you the opportunity to work at the forefront of early clinical and translational research within Cardiovascular, Renal and Metabolism (CVRM), one of AstraZeneca’s main therapy areas. In a multidisciplinary environment you will play a key role in progressing a rich and diverse pipeline of both small and large molecule candidate drugs. You can be located in Cambridge at AstraZeneca’s vibrant UK R&D site.

The AstraZeneca CVRM Research group in Cambridge UK is seeking to recruit a high calibre scientist to enable progression of a growing drug project portfolio. Highly motivated scientists are encouraged to apply for the opportunity to join our team of professionals who are passionate about advancing science, to discover and develop novel therapeutics that will benefit patients.

Role Overview

You will play an active role in implementing and executing scientific research and development within the CVRM group, enabling the prosecution of a rapidly growing portfolio of small molecule and biologics drug projects. This is a "hands-on," laboratory based scientific and technical role in our in vitro metabolism team supporting projects from target validation to lead optimisation phases.

Role specifics

This position will be laboratory based and you will be responsible for several technical and experimental processes to support the CVMR Metabolism Research group.

Responsibilities

• Responsibility for design, execution and analysis of in vitro and ex vivo assays.
• Contribute to and review new target proposals
• Predominantly functional and cellular screens supporting Target Validation, Lead Isolation and Lead Optimisation for the CVRM Research Area. Often cell signalling and second messenger assays including routine compound profiling to drive SAR campaigns.
• Communicate results, conclusions and recommendations to colleagues, line manager and multi-disciplinary teams.
• Perform extended and specialised characterisation when required for projects.
• Record experiments in lab books and databases.
• Play a leading role in assay development and optimisation of disease relevant primary and transfected cell assays.
• You would report to an expert member of staff and would be encouraged to be able to plan your daily work within direction set by your supervisor.

You will:

• Be asked to provide interpretation of assay results
• Work within a line and/or matrix/project team.
• Demonstrates scientific rigor in assessing own data and that of others.

Requirements Essential

• Be a "hands-on" expert with in vitro models and methodologies.
• Enthusiasm for laboratory work, scientific curiosity
• Experience in running in vitro biochemical and cellular assays to provide potency and activity readouts, including use of primary and recombinant cell lines.
• Significant cell culture experience.
• Experience in data analysis and interpretation
• Experience of working in accordance with established SOPs and codes of conduct.
• Capability to work seamlessly with cross-functional project teams to provide high quality data in a timely manner.
• Demonstrable ability to work within a line and/or matrix/ cross-functional project team.
• Strong interest in providing materials and data for scientifically challenging work
• Strong organisational, time management and communication skills
• Strong, demonstrable analytical ability
• Good oral and written communications skills

Desirable

• Background in metabolic disease research areas.
• Experience of working with disease relevant primary cell assays associated with one or more of the following disease areas: diabetes, obesity, NASH or dyslipidaemia.
• An understanding of biological sciences, familiarity with the drug discovery process.
• Experience in running in vitro biochemical & cellular assays to provide potency and efficacy readouts, including use of recombinant cell lines.
• Experience of cell based signalling assays
• IC50/EC50 determination
• Experience working in pharmaceutical or biotech environment

Behavioural competencies

• Hard working, organised, balanced and meticulous with an ability to work well under pressure.
• Adaptable and a team player with a conscientious attitude and enthusiasm
• Desire to learn

Education

Degree in one of the Life Sciences disciplines with PhD or equivalent post-graduate or industry experience.

Advert opening date - 15th of July 2021

Advert closing date - 15th of August 2021

Date Posted

Closing Date

AstraZeneca embraces diversity and equality of opportunity.  We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills.  We believe that the more inclusive we are, the better our work will be.  We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics.  We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.