YOUR TASKS AND RESPONSIBILITIES

The primary responsibilities of this role, Development Associate Protein Purification , are to: 

• Act as subject matter expert in developing and optimizing manufacturing process under the direction of the development scientist, project lead or DSP TDT representative;
• Execute scientific experiments under the direction of development lead Scientist;
• Be actively involved in experimental designs, data collation, data analysis, protocol and report writing under the direction of the development lead scientist;
• Train others in the execution of experimental study execution and in scaled-up operations.
• Work with Team Lead to plan, schedule and execute bench-scale and process scale-up purification trains in Development lab;
• Work together with development lead scientist, active involve in the communication and knowledge transfer to Clinical Manufacturing group;
• Actively support clinical manufacturing operations as needed, and provide process knowledge on the manufacturing floor as requested;
• Execute pathogen safety experiments and assist in data collation, protocol and report writing under the direction of the pathogen safety lead scientist.

WHO YOU ARE

Your success will be driven by your demonstration of our LIFE values.  More specifically related to this position, Bayer seeks an incumbent who possesses the following:

Required Qualifications:

• B.S. in Biochemical Engineering, Biochemistry, Biological Sciences, Chemical Engineering or related field with a minimum of one year of experience in biopharma, healthcare or manufacturing environment, or M.S. in Biological Sciences, Biochemistry, Chemistry, or related field experience in biopharma, health care or manufacturing environment, or an equivalent combination of education and experience;
• Ability to understand and execute bench scale purification development techniques including chromatography using AKTA and Avant workstations, dead end filtration, tangential flow filtration, and various protein analytical assays such as  Liquid chromatography - mass spectrometry (LC-MS) ,  Ultra-violet visible (UV-Vis)  Spectrophotometry,  Dynamic light scattering (DLS) , Nanoparticle Tracking Analysis (NTA) , Quantitative polymerase chain reaction (qPCR) , Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) , High performance liquid chromatography (HPLC) , Capillary electrophoresis (CE) ,  Homogeneous time resolved fluorescence (HTRF) ,  Gyros and  Enzyme-linked immunoassay (ELISA);
• Be able  to follow written and/or verbal instructions in the performance of experiments, assays, and/or method development procedures;
• Be able  to solve scientific problems with deductive reasoning;
• Be able  to troubleshoot process and analytic equipment issues;
• Be able  to summarize, interpret, and review experimental data for accuracy;
• Be able  to review scientific publications and fundamental scientific concepts and apply them to purification development and process modelling;
• Good verbal and written communication skills;
• Experience with Design Of Experiment (DOE), automation, database construction and analysis;
• Experience working with automated liquid handler (eg Tecan), automated Ultrafiltration-diafiltration (UFDF)  systems (eg Akta Crossflow and Avants);
• Experience working with data software (eg JMP, MATLAB, Excel Basic, Aspen Plus and SuperPro Designer);
• Experience working with mechanistic modelling (eg. HTPD, Cadet and ChromX);
• Experience working with vendors to evaluate cutting-edge technologies relevant to process development and clinical manufacturing.