Sr Scientist- Cell and Molecular Biology

Waltham, MA

Become a key player in the discovery of innovative medicines

At AstraZeneca we win through science, it’s at the heart of our every success.  We continuously forge partnerships to expand our science to help pursue world-class medicines in new ways, combining our people’s exceptional skills with those of people from all over the globe.  As a Senior Scientist, you’ll play a pivotal role in channeling our scientific capabilities to make a positive impact on changing patients’ lives.

We are seeking a highly motivated and skilled PhD-level scientist with a strong background in molecular and cell biology to join the AstraZeneca Oncology Safety Sciences team at our suburban Boston, MA research complex. The successful candidate will perform in vitro investigative studies to assess the role of therapeutic targets and pathways on normal tissue/cellular function.  You will exploit human microtissues with gene knockdown/knockout techniques alongside pharmacological tools to seek a mechanistic understanding of unanticipated toxicities from projects developing novel oncology medicines.  You will work closely with a team of scientists to apply cutting edge technologies and push the boundaries of predictive safety science with our mission in mind: to discover safe innovative medicines for the patients that need them.

The Role

You will be an integral contributor to AstraZeneca’s early oncology pipeline, working to support drug discovery by:

• Developing testable hypotheses and driving scientific learning by building an understanding of biology around novel oncology targets and pathways
• Designing and executing molecular, biochemical, and/or cellular experiments to determine the effects of oncology agents on normal tissue function  
• Leveraging multi-modal approaches and techniques (such as multi-omics, gene editing, flow cytometry, and confocal imaging) for the development of physiologically-relevant cellular assays to dissect biological responses at a mechanistic level

Minimum Requirements

• A PhD in molecular biology, pharmacology, immunology, molecular toxicology or similar discipline with at least 2 years of post-doctoral research
• Proven experience and expertise in molecular and cellular biology
• Research experience in stem cell biology, epigenetics, 3D culture systems, and/or single-cell approaches would be an advantage
• A strong publication record demonstrating scientific excellence applying molecular techniques to advance understanding of cellular biology
• Outstanding oral presentation and written communication skills
• Highly motivated, innovative scientist with strong influencing skills and a collaborative, team-oriented mindset

At AstraZeneca, we place a strong emphasis on individual talent development. Join us and you will be able to develop your scientific leadership by working together with leaders in cell biology, advanced imaging, ‘omic technologies, microphysiological systems, drug discovery and predictive safety science.

Next Steps – Apply today!  Go to https://careers.astrazeneca.com/ and type in R-072484

To be considered for this exciting opportunity, please complete the full application on our website at your earliest convenience – it is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity.  If you know someone who would be a great fit, please share this posting with them.

Date Posted

Closing Date

AstraZeneca embraces diversity and equality of opportunity.  We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills.  We believe that the more inclusive we are, the better our work will be.  We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics.  We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.