Position:         HTS Senior Research Scientist

Salary:             Competitive with excellent benefits

Location:        Alderley Park, Cheshire prior to relocation to Cambridge

At AstraZeneca, we’re not afraid to do things differently. We’re building a new kind of organisation to reset expectations of what a bio-pharmaceutical company can be. This means we’re opening up new ways to work, pioneering cutting edge methods and bringing unexpected teams together.

We are looking to recruit Senior Research Scientists to join our Global High Throughput Screening (HTS) Centre in Alderley Park, prior to relocation to a new, state-of-the-art R&D centre in Cambridge. HTS is the only department within our world-leading pharmaceutical business that focuses unequivocally on Hit identification. This means you’ll get unrivalled exposure to the drug discovery process, working on multiple projects across therapeutic areas in a culture that fosters collaboration and open innovation – find out more at http://openinnovation.astrazeneca.com/

Our HTS Centre aids the definition of screening cascades in discovery programmes, uses cutting-edge assay technologies to generate high-quality screening data and delivers robust data packages to pursue tractable hit series. Whether you’re looking to share your experience, or get the training to build it, you could be part of a team that uses world-class science and technology to deliver the most innovative tools for drug discovery.

If you’re inspired by the possibilities of science to make a difference and ready to discover what you can do – join us.

Main duties and responsibilities

Taking on a lab-based role, you’ll be tasked with delivering excellence in data generation within Hit Discovery for cellular and biochemical targets – enhancing the delivery of projects in compliance with SHE requirements. We’ll also expect you to capitalise on publication and collaboration opportunities and to mentor less experienced scientists. You’ll have every tool to acquire both practical and academic skills and become a true expert in your field.

Essential requirements

• BSc/PhD in a relevant biology discipline
• Flexibility to work at Alderley Park, Cheshire initially and then relocate to Cambridge
• Demonstrable experience in cell and/or biochemical screening approaches and ability to troubleshoot screening problems
• Ability to drive the practical application of new assay approaches to screening and drug discovery science in Hit Discovery
• Familiarity with technology-rich lab environments.

Desirable requirements

• Experience in several cellular and biochemical screening technologies
• Assay Development, cascade design and drug discovery project team experience
• Phenotypic screening, imaging/flow cytometry experience
• Understanding of state-of-the-art assay technology platforms
• Publication record and/or experience of presenting scientific data
• Strong understanding of the analysis and interpretation of screening data to understand mechanism of target engagement
• Experience of applying high volume/complexity data generation methods to drug discovery projects
• Experience of small molecule screening and/or fragment-based screening.

We welcome your application for this exciting opportunity no later than Wednesday 11th September 2019

Date Posted

Closing Date

AstraZeneca embraces diversity and equality of opportunity.  We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills.  We believe that the more inclusive we are, the better our work will be.  We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics.  We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.