岗位职责：

• You will be responsible for designing, executing and reporting the results of experiments to support projects from target identification and validation through to clinical candidate selection.

• You will use a wide range of advanced methodologies to probe mechanisms and test drugs, primarily through in vitro and ex vivo cell-based immunological assays.

• The successful candidate will have excellent oral and written communication skills, work well independently and as part of a team, and be able to execute on multiple projects simultaneously.

• With limited supervision, the role includes developing and optimizing methodologies and assays and making decisions using good scientific judgment.

• The position is a hands-on, laboratory based role with no direct reports.
  

任职资格：

• Ph.D. in Immunology, cell biology or related field with a minimum of 3 years’ experience in pharmaceutical/biotech industry or in an academic setting.

• Outstanding candidates with a Master’s degree with a minimum of 7 years’ industry experience will also be considered

• Solid training and background in cellular immunology, preferably with expertise in immune-oncology, autoimmunity, and associated rodent pre-clinical models.

• Ability to independently design, perform and interpret data derived from cellular immune function assays.

• Broad expertise and familiarity with assays and technologies commonly used to assess immune endpoints (e.g., MLR, antigen-specific T/APC cultures; ELISA/ELISPOT, qPCR); solid cell line and primary immune cell tissue culture skills.

• Experience in multi-parameter FACS analysis and proficiency in downstream FACS data analysis using FlowJo.

• Ability to organize and communicate complex data sets in a clear and concise manner to key stakeholders from diverse backgrounds.

• Basic understanding of statistics, data analysis, and assessment of reproducibility and reliability of experimental data.

• Ability to contribute at a scientific and strategic level to drug discovery research programs in immunology, including proposal and identification/validation of novel targets.

• S/he should be a strong team player with excellent oral and written communication skills and a demonstrated ability to work independently to design experiments, generate and interpret data, troubleshoot, and suggest next steps.

• Demonstrated project lead experience in an academic or industrial research setting.

• Demonstrated experience mentoring and training junior scientists.

• Proven experience with biologics drug discovery and demonstrable knowledge of multiple large molecule formats and associated technologies.

• Experience with in vivo immune-mechanistic or autoimmune/cancer disease models in the mouse system and their application towards pharmacological assessment of drug efficacy and mode-of-action.

• Demonstrable experience with in vitro pharmacology assays involving large or small molecule drugs, e.g., experimental design and replication, titration and potency value determination, etc.

• Experience with isolation, characterization, and functional testing of primary human immune cells from healthy donors or disease patient-derived materials.

• Genetic engineering of reporter cell lines and/or primary cells: molecular biology skills (e.g., plasmid manipulation and transfection, clonal selection) and experience with gene editing technologies (e.g., si/shRNA and CRISPR/Cas9 via transfection or retroviral delivery).

上班地址：上海市外高桥保税区富特中路288号