Career Category

Postdoctoral

Job Description

HOW MIGHT YOU DEFY IMAGINATION?

Do more with the knowledge you’re working hard to acquire and the passion you already have. At Amgen, our shared mission—to serve patients—drives all that we do. It is key to our becoming one of the world’s leading biotechnology companies, reaching over 10 million patients worldwide. Through this program, you will acquire the valuable hands-on skills and foundational experience to become the professional you are meant to be in your chosen field.

Postdoctoral Fellow – Pharmacokinetics and Drug Metabolism

Live

This could be your everyday

Let’s do this. Let’s change the world. During this program, you will be provided with an enriching environment to inspire innovation that will contribute to the development of human therapeutics.

The Pharmacokinetics and Drug Metabolism (PKDM) Department at Amgen is seeking a highly motivated postdoctoral fellow within the fields of biophysical chemistry and cellular biology to determine the underlying principles driving the endocytosis and intracellular processing of multi-specific biologics. A primary aim of this endeavor will be to develop in vitro cell-based assays to quantify therapeutic protein trafficking in relation to defined molecular attributes, with the overall goal of correlating these observations to the in vivo pharmacokinetics.

The initial focus of the postdoctoral fellow will be to identify how bound antigen impacts the binding of the therapeutic protein to specific cell surface receptors. Subsequently, the postdoctoral fellow will then evaluate how/if the modified receptor interactions influence cellular uptake, recycling, and/or degradation of related therapeutic modalities within several model cell systems.  The fellow will then explore how these modulations affect the overall pharmacokinetics of the therapeutic proteins in pre-clinical models.

Responsibilities:

• Design and implement both solution and cell-based biophysical assays to study protein-protein interactions (affinity/kinetics/cell trafficking) involving different bispecific molecular formats against target antigens and Fc receptors (e.g. FcRn)

• Develop, isolate, and characterize immortalized cell lines and primary cells.

• Conduct cell trafficking analysis via transcytosis & recycling assays (Transwell formats) with ELISA detection, and through quantitative colocalization analysis using fluorescence microscopy

• In vitro cell clearance assay development

The postdoctoral position is for 3 years with the option to extend for an additional year.

Win

Here’s what it takes to Win

We are all different, yet we all use our unique contributions to serve patients. The dedicated individual we seek is a scientist with these qualifications.

Basic qualifications

• PhD at the time of appointment

Preferred qualifications

• PhD in biophysics, biochemistry, immunology, or cellular and molecular biology is preferred

• Strong proficiency in one or more of the following techniques: ligand-receptor biophysical assays (SPR, Forte Bio, SwitchSense, calorimetry, etc.), HPLC and SEC-MALS, flow cytometry, mammalian cell culture, confocal microscopy, imaging analysis

• Working knowledge of the factors mediating the pharmacokinetics of protein therapeutics (e.g. monoclonal antibodies and Fc-fusions)

• Motivated individual capable of working both independently and collaboratively

• Knowledge of cell trafficking and transport studies a plus

• Excellent written and verbal skills

• Demonstration of past scientific accomplishments through publications

Thrive

What you can expect of us

As we work to develop treatments that take care of others, so we work to care for our teammates’ professional and personal growth and well-being.

• Vast opportunities to learn and move up and across our global organization

• Diverse and inclusive community of belonging, where teammates are empowered to bring ideas to the table and act

• Generous Total Rewards Plan comprising health, finance and wealth, work/life balance, and career benefits

Apply now

for a career that defies imagination

In our quest to serve patients above all else, Amgen is the first to imagine, and the last to doubt. Join us.

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Equal Opportunity Statement

Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

We will ensure that individuals with disabilities are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request an accommodation.

Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance.