Career Category

Postdoctoral

Job Description

HOW MIGHT YOU DEFY IMAGINATION?

You’ve earned your degree. How will you use that achievement to reach your goals? Do more with the knowledge you’ve worked hard to acquire and the passion you already have. At Amgen, our shared mission—to serve patients—drives all that we do. It is key to our becoming one of the world’s leading biotechnology companies, reaching over 10 million patients worldwide. Become the professional you are meant to be in this meaningful role.

Postdoctoral Fellow – Biologics (Biologic protein expression, intracellular protein phase separation, and cell phenotype analysis)

Live

What you will do

Let’s do this. Let’s change the world. Let’s do this. Let’s change the world. During this program, you will be provided with an enriching environment to inspire innovation that will contribute to the development of human therapeutics.

The lab of Haruki Hasegawa in Biologics Department at Amgen South San Francisco is seeking a postdoctoral fellow to investigate the mechanism of intracellular protein crystallization and LLPS induced by the over-expression of various condensation-prone secretory cargo proteins including mAbs and antibody fragments. The lab’s research interests include the elucidation of unique physicochemical properties embedded in proteins that crystallize intracellularly, in-depth characterization of intracellular protein crystallization and protein phase separation events, detailed understanding of cell morphological changes and signaling events during intracellular protein crystallization events, and biotechnological application of ER-associated protein inclusion bodies and intracellular protein crystals.

The initial research projects of the selected postdoctoral fellow are:

characterizing the roles of post-translational modifications and protein-protein interactions in intra-ER protein crystallization event; elucidating the solubility and condensation propensity of a human IgG that induces LLPS protein droplet in the ER lumen during over-expression; exploring the merits of identified effector genes in enhancing difficult-to-express secretory protein production, to list a few potential projects.

The postdoctoral fellow is expected to develop an independent line of research based on initial projects and to present at scientific conferences and publish in leading journals. The successful candidate will operate in a highly collaborative environment, with opportunities to interact with other postdoctoral fellows, scientists, and drug discovery teams while having access to state-of-the art protein expression technologies and resources at core facilities.

The postdoctoral position is for 3 years with the option to extend for an additional year.

Win

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The dedicated individual we seek is a scientist with these qualifications.

Basic qualifications

Ph.D. at the time of appointment

Preferred qualifications

• Ph. D. in molecular and cell biology, biochemistry, or related life science field
• Solid publication record and strong oral and written communication skills
• Extensive cell imaging experience in immunofluorescent microscopy (EPI, confocal, high content, etc)
• Proficient skills in flow cytometry, cell sorting, intracellular signaling assays, protein purification, and chromatography
• Cell phenotype morphometric analysis using algorithms and machine learning
• Solid knowledge on secretory protein biosynthesis, folding, assembly, trafficking, and secretion
• Familiarity with various stress response signaling pathways and associated cell-based assay methods
• Research experience in one or more the following areas:
• Intracellular protein phase separation, protein crystallization, or protein condensation
• Cell-based assay development and signaling pathway elucidation
• Recombinant antibody production and expression optimization
• Biochemical and biophysical characterization of purified recombinant antibodies

Thrive

Some of the vast rewards of working here

As we work to develop treatments that take care of others, so we work to care for our teammates’ professional and personal growth and well-being.

• Full support and career-development resources to expand your skills, enhance your expertise, and maximize your potential along your career journey
• A diverse and inclusive community of belonging, where teammates are empowered to bring ideas to the table and act
• Generous Total Rewards Plan—comprising health, finance and wealth, work/life balance, and career benefits—with compensation and benefits rated above 4 stars (out of 5) on Glassdoor

Apply now

for a career that defies imagination

Objects in your future are closer than they appear. Join us.

careers.amgen.com

Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance.