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Job Description

HOW MIGHT YOU DEFY IMAGINATION?

If you feel like you’re part of something bigger, it’s because you are. At Amgen, our shared mission—to serve patients—drives all that we do. It is key to our becoming one of the world’s leading biotechnology companies. We are global collaborators who achieve together—researching, manufacturing, and delivering ever-better products that reach over 10 million patients worldwide. It’s time for a career you can be proud of. Join us.

Principal Scientist - PBPK, Pharmacokinetics and Drug Metabolism

Live

What you will do

Let’s do this. Let’s change the world. In this vital role you will add substantial scientific expertise to the discovery and non-clinical development of small molecule therapeutics using physiologically based pharmacokinetic modeling (PBPK). You will be responsible for establishing and implementing PKDM strategy to achieve project team goals integrating PBPK simulations with other aspects of drug discovery including disease biology, chemistry/protein sciences, toxicology and clinical pharmacology to advance the best therapeutic candidates. In addition, you will make meaningful and innovative contributions to the fundamental understanding of the factors that affect the absorption, distribution, and clearance of small molecule therapeutics.

In this position, your core responsibilities are to:

• Serve as a functional representative and subject matter expert on PBPK modeling of small molecule therapeutics and collaborate with scientists across our PKDM scientific community

• Evaluate, implement and develop in vitro and in silico tools to support the prediction of pharmacokinetics (PK) and drug interactions (DDIs) in humans

• Articulate risk and mitigation strategies for human PK predictions, clinical dose projections and DDI study design

• Design and complete IND and NDA-enabling PBPK simulations to support regulatory submissions

In addition to the core responsibilities, the position provides the opportunity to pursue scientific inquiries into the fundamental physiological and biochemical factors that determine the absorption, distribution, and clearance of small molecule and protein therapeutics.

Win

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The PBPK hands on experienced professional we seek has to meet next qualification requirements.

Basic Qualifications

Doctorate degree and 2 years of drug discovery and/or development experience

Or

Master’s degree and 5 years of the relevant experience

Or

Bachelor’s degree and 7 years of the relevant experience

Preferred Qualifications:

• A Ph.D. in pharmaceutical, chemical, or biological science (or BA/MS with equivalent experience) and 6+ years of drug discovery and/or development experience

• Hands on expertise using PBPK platforms (e.g. Simcyp, GastroPlus, Phoenix WinNonlin, or Matlab);

• Knowledge of PK, PD and/or distribution of small molecule therapeutics.

Critical thinking and demonstrated ability to communicate with team members across broad disciplines. Effective oral and written communication skills are essential.

Thrive

What you can expect of us

As we work to develop treatments that take care of others, we also work to care for our teammates’ professional and personal growth and well-being.

• Vast opportunities to learn and move up and across our global organization

• Diverse and inclusive community of belonging, where teammates are empowered to bring ideas to the table and act

• Generous Total Rewards Plan comprising health, finance and wealth, work/life balance, and career benefits

Apply now

for a career that defies imagination

In our quest to serve patients above all else, Amgen is the first to imagine, and the last to doubt. Join us.

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Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

Amgen requires all staff in the United States and Puerto Rico to be vaccinated from COVID 19 as a condition of employment. In accordance with applicable law, Amgen will provide reasonable accommodations to staff members who qualify on the basis of a medical reason or a sincerely held religious belief, practice, or observance. Such accommodation may not pose an undue hardship to Amgen, its operations, or its staff.