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Job Description

HOW MIGHT YOU DEFY IMAGINATION?

You’ve earned your degree. How will you use that achievement to reach your goals? Do more with the knowledge you’ve worked hard to acquire and the passion you already have. At Amgen, our shared mission—to serve patients—drives all that we do. It is key to our becoming one of the world’s leading biotechnology companies, reaching over 10 million patients worldwide. Become the professional you are meant to be in this meaningful role.

Process Development Scientist (Drug Substance Technologies)

Live

What you will do

Let’s do this. Let’s change the world.

Amgen’s Process Development organization is seeking a Scientist to join the Pre-Pivotal Drug Substance Technologies organization and be responsible for developing innovative solutions to drive our small molecule pipeline. The scientist will be involved in the dynamic transition of new programs / molecular targets from Discovery Chemistry, into the clinical development space, and through Clinical Proof of Concept (Early Phase Chemical Development). The scientist will be primarily involved in the use of innovative process technologies to drive route selection activities and the development of chemical processes to be used in the manufacture of Drug Substance to help drive our growing and dynamic Small Molecule Portfolio.

Scientific/Technical Responsibilities

• Develops technology to manufacture drug candidates in a practical, efficient, and safe manner.
• Champions innovative applications of technology [High Throughput Experimentation, Biocatalysis, Flow chemistry, process analytical technologies (PAT)] to solve challenging synthetic problems and drive improvements in sustainability, process efficiency, safety, and cost of goods.
• Provides significant contributions to drug substance development teams (e.g., product and process development teams, product quality teams) by providing drug substance updates, documentation, data interpretation, technical recommendations, etc.
• Serves as a technical expert and keeps current in organic chemistry and applications of process technology in pharmaceutical development including literature and technology development.
• Improves the technical or scientific capabilities of the department and routinely answers questions on or resolves scientific/technical issues.
• Collaborates in cross-functional teams to develop Amgen’s pipeline.
• Works cross-functionally to deliver regulatory documents and supporting documentation in support of Amgen’s regulatory filings.
• Delivers processes amenable to manufacturing operations and carry out deliveries of drug substance in a cGMP manufacturing environment.
• Ability and desire to lead synthetic route development, drive new technology development, and eventually program management.
• Effectively participates on drug substance development teams as a team member.
• Works effectively in a multi-disciplinary team of chemists, engineers and attribute scientists.
• Collaborates with other scientists and professionals outside the department

Win

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is a individual with these qualifications.

Basic Qualifications

• Doctorate degree or Doctorate degree by December 2022 OR
• Master’s degree and 4 years of scientific experience OR
• Bachelor’s degree and 6 years of scientific experience

Preferred Qualifications

• Doctorate degree in Organic Chemistry, Medicinal Chemistry or Synthetic Chemistry
• Post-doctoral research experience
• Track record of demonstrated scientific accomplishments in the field of organic chemistry
• Ability to champion new technologies
• Experience in the pharmaceutical / biotech or related industry that includes participation and contribution to scientific project teams
• Familiarity with common industrial unit operations including crystallization (batch and continuous mode), filtration and drying
• Familiarity with the use of design of experiments (DoE) and Process Analytical Technology (PAT) techniques
• Familiarity with laboratory automation, data analysis and visualization techniques and tools
• Familiarity with Environmental Health and Safety expectations for chemical laboratories
• Familiarity with current Good Manufacturing Practices for preparing drug substances and intermediates
• Demonstrated ability to effectively work in a fast-paced team environment
• Excellent interpersonal, presentation, written and verbal skills
• Knowledge of basic office and chemistry software including Microsoft Word, Excel, PowerPoint, ChemDraw, and SciFinder

Thrive

Some of the vast rewards of working here

As we work to develop treatments that take care of others, we also work to care for our teammates’ professional and personal growth and well-being.

• Full support and career-development resources to expand your skills, enhance your expertise, and increase your potential along your career journey
• A diverse and inclusive community of belonging, where teammates are empowered to bring ideas to the table and act
• Generous Total Rewards Plan—comprising health, finance and wealth, work/life balance, and career benefits—with compensation and benefits rated above 4 stars (out of 5) on Glassdoor

Apply now for a career that defies imagination

Objects in your future are closer than they appear. Join us.

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