• Lead/develop downstream processes for novel pipeline products and monoclonal antibodies for research and development efforts

• Perform process optimization and validation based on design of experiment approaches of downstream processes for existing clinical products in preparation for Phase 3/commercial manufacturing

• Lab-scale purification runs to support analytical, research, and GLP needs

• Scale-up, tech transfer, and CMO manufacturing support

• Compile data to support/contribute to technical/development reports for technology transfer and regulatory submission

• Manage Purification Development resources and strategic planning to support early and late stage projects.

• Coordinate and collaborate with Discovery and other CMC functions and develop strategies to meet project as well as corporate timelines

• Maintain scientific excellence and attention to detail

• Design and conduct experiments, collect and analyze data, write development reports

• Drive innovation through deep understanding of new technologies and methods in purification development

• Contribute to the IND filings

Requirements for Research Associate, Sr. Research Associate or Scientist:

1. BS/BA or MS or PhD in Chemical Engineering, Biotechnology, Cell Biology, Molecular Biology, Biochemistry or related field. Number of years of industry experience commensurate with job titles

2. Hands-on experience in purification techniques and in using AKTA systems

3. Experience in purification process development for monoclonal antibodies, bispecific antibodies, Fc-fusions and other therapeutic proteins

4. Expertise in purification scale-up principles, competency in planning and executing hands-on experimentation, and the ability to work well within a team dynamic in a fast-paced work environment

5. Experience with process analytics including HPLC, SDS-PAGE

6. Exceptionally strong communication and problem-solving skills and knowledge of Design of Experiment approaches for process optimization

7. Ability to work independently and multitask in a fast-paced environment

8. Responsible, organized and disciplined record keeping

9. Self-motivated, collaborative, and effective communication skill

上班地址：上海张江哈雷路866号