Scientist, ADPE

Cambridge, UK

Competitive salary, excellent benefits

Meaningful Impact. Make a more meaningful contribution Impact patients’ lives every day

Make a more meaningful impact in your career, with greater ownership and accountability to make a contribution. And in return… we’re looking for people driven by making a difference to patients’ and society, dedicated to doing the right thing.

ADPE is responsible for the discovery and optimisation of biological candidate drugs to support all therapy area drug discovery pipelines and for the development of in-house biologics discovery platforms and novel drug modalities to support future drug discovery efforts.

We have an opportunity for a Scientist  who has a good understanding and experience of high throughput recombinant protein engineering and production in relation to biologics discovery.  In this role you will be responsible for producing protein therapeutics in a high throughput automated process, setting up and running of automated processes for DNA production, transfections, purifications and QC of final protein biologics at a high throughput scale.

What You’ll do

• Generates recombinant expression vectors and nucleic acid preparations to allow for protein expression, particularly in relation to antibody and next-generation biologics development at a high throughput scale
• May also perform recombinant protein expression, using mammalian expression systems, purification (e.g. automated liquid chromatography eg AKTA) and characterisation (e.g. SDS-PAGE, SEC-HPLC, OCTET)
• Analyses data, making detailed observations and interpretation of results and understands the implications of the data in relation to the drug discovery process.
• Demonstrates professional interpersonal communication by establishing good working relationships with team and department members and others within the company
• Ability to work effectively and collaboratively in a multi-disciplinary team and works closely with other  scientists in relation to day to day working
• Understands and applies principles, theories and techniques used in cloning, expression & purification  of protein biologics, to support drug and technology projects, with high level of attention to detail and providing solutions to a variety of process related problems
• Pro-actively contributes to development of new or improved high throughput protein expression processes
• Prepares appropriate documentation such as electronic laboratory notebooks, contributions to patents and IND reports and conducts work according to current codes of practice (health and safety legislation, etc.) and all other relevant internal AstraZeneca standards and external regulations
• Presents clear and concise findings at internal (intra- and inter-departmental) project team and community of practice meetings
• Demonstrates strong interpersonal communications by establishing and using existing working relationships with ADPE department members, Discovery Sciences and BPD within the company
• Provides training for students or members of department in processes, where necessary

Essential Criteria

• Level 4/5 qualification e.g. NVQ, apprenticeship or Bachelor/Master of Science degree in life sciences
• Experience in designing and conducting laboratory experiments and processes within the field of molecular biology & protein expression
• Professional communication skills and excellent attention to detail, capable of developing good working relationships with diverse individuals across organisational boundaries and experience working within a team environment
• Has scientific curiosity and proactively develops knowledge
• Acts with integrity and does the right thing

Desirable Criteria

• Master’s degree in related field
• Protein purification & use of  high throughput automation systems eg Hamilton

Pioneer a new future to meet global healthcare challenges

At AstraZeneca we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learning, growth and development.

So, what’s next?

Complete your application before the below closing date.

This role is open from 2 August 2021 and welcome with your application no later than 16 August 2021.

Where can I find out more?

Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/

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Date Posted

02-Aug-2021

Closing Date

15-Aug-2021

AstraZeneca embraces diversity and equality of opportunity.  We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills.  We believe that the more inclusive we are, the better our work will be.  We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics.  We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.