AstraZeneca’s vision in Oncology is to push the boundaries of science to change the practice of medicine, transform the lives of patients living with cancer, and to ultimately eliminate cancer as a cause of death. A broad pipeline of next-generation medicines is focused on bringing novel concepts in immuno-oncology to unmet medical need.

The Boston R&D site located in Waltham, MA is situated within a biopharma cluster of academic research institutions, medical centers, pharmaceutical companies and biotech startups.   The Boston region is consistently ranked #1 globally for biotech research, investment, talent recruitment and lab space. 

Main Responsibilities

You will work in a laboratory within the Oncology Research group designing, conducting and analyzing in vitro and in vivo experiments to assess the function of our candidate oncology drugs and dissect the mechanism of action of novel therapeutics. You will also review emerging literature and internal data to identify new targets and contribute to target validation activities.

Essential Requirements

• Bachelor’s or advanced degree in tumor biology, applied biology, biochemistry, pharmacology or a related field
• Depth of understanding of solid tumor and hematology cancer models
• Experience with a range of in vitro skills for the analysis of human tumor cell function (e.g. cell culture, cell signaling bioassays, high-content imaging, and cell death measurement in primary and cell line cultures)
• Experience conducting flow cytometry and visualizing/quantitating high content multi-parameter flow data
• Molecular biology skills including assessment of intracellular signaling and generation of engineered cell lines, generating and/or analyzing transcriptomic data
• Strong interpersonal and collaboration skills together with evidence of having used these to support problem solving and delivery in a collaborative environment.

Desirable Requirements

• Experience in the evaluation of immune function and in the application of complex immunological assays
• Experience working with cell death modulating agents, with biologics including antibodies and antibody-drug conjugates and evaluation of transcriptomic datasets
• Familiarity with nano-medicine drug delivery
• Knowledge of the drug discovery process and publications in credible scientific journals

Date Posted

Closing Date

AstraZeneca embraces diversity and equality of opportunity.  We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills.  We believe that the more inclusive we are, the better our work will be.  We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics.  We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.