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Job Description

HOW MIGHT YOU DEFY IMAGINATION?

You’ve earned your degree. How will you use that achievement to reach your goals? Do more with the knowledge you’ve worked hard to acquire and the passion you already have. At Amgen, our shared mission—to serve patients—drives all that we do. It is key to our becoming one of the world’s leading biotechnology companies, reaching over 10 million patients worldwide. Become the professional you are meant to be in this meaningful role.

Scientist - Enzymology of Protein and RNA Degradation

Live

What you will do

Let’s do this. Let’s change the world. In this vital role you will be a part of our Biochemistry and Structural Biology (BSB) group. We are seeking an accomplished Scientist to contribute to the Induced-Proximity Platform (IPP) organization tasked with the discovery of novel therapeutics in the Targeted Protein and RNA Degradation fields.

The BSB group is focused on enhancing our understanding of the biochemistry of ubiquitin ligases and other related enzymes involved in cellular protein degradation. These efforts including the discovery of Proteolysis and Ribonuclease-targeting Targeting Chimeras (PROTACs and PRIBOTACs) and Molecular Glues to advance Amgen’s drug discovery pipeline of intractable and difficult-to-drug therapeutic targets.

This is a unique opportunity for those who are interested in conducting basic research in the targeted macromolecule degradation field while directly impacting therapeutic discovery programs at a premier organization.

The candidate will work collaboratively with researchers across multiple functions within the IPP department as well as across disease therapeutic areas and the Therapeutics Discovery organization. The successful candidate will also work with external partners and contract research organizations (CROs) and have the opportunity to present work at national and international conferences.

Key Responsibilities

• Planning, design, implementation, and documentation of laboratory studies related to the studying of protein complexes involved in protein degradation.
• Design of DNA constructs and the use of rational and computational tools for the engineering of protein constructs to ensure successful protein expression, purification and structural determination.
• Perform expression, purification, and characterization of recombinant proteins to support various aspects of drug discovery efforts related to Targeted Protein and RNA Degradation.
• Perform biochemical, biophysical and structural characterization of protein complexes.
• Study protein-protein and protein-RNA interactions.
• Collaborate within and across interdisciplinary teams to advance our understanding of Targeted Protein and RNA Degradation mechanisms.

Win

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The qualified professional we seek is a Scientist with these qualifications.

Basic Qualifications

• PhD in Biochemistry, Protein Chemistry, Structural Biology, Chemistry or Chemical Engineering.
• Strong scientific reasoning, data analysis and problem-solving skills as evidenced by high impact scientific publications.
• Highly motivated and in a cross-functional and fast-paced environment.
• Work independently to plan, lead, and conduct experiments.
• Ability to develop a deep understanding of projects aimed at discovering novel therapeutics.
• Strong understanding of basic protein biochemistry and biophysics principles, including those pertaining to enzyme kinetics, protein complex formation, and protein-substrate interactions.

Preferred Qualifications

• 2+ years of postdoctoral or industry experience.
• Prior experience with the purification and the biochemical and/or biophysical characterization of challenging proteins including protein and RNA complexes.
• Expert user of FPLC (AKTA PURE or Avant) and HPLC systems (Waters or Agilent).
• Solid understanding of protein analytical techniques to study macromolecules including SEC, SEC-MALS, DLS, thermal shift assay, mass photometry and LC-MS.
• Experience in protein expression in E.coli and insect cells.
• Familiarity with protein modeling and design tools such as MOE, Rosetta or Schrödinger.
• Knowledge of protein/RNA degradation mechanisms and in particular the biochemistry of ubiquitin ligases or RNAases.
• Practical knowledge of techniques to investigate protein interactions such as HDX, XL-MS, SPR and SAXS is a plus.
• Practical experience in structural biology including crystallography or cryoEM as demonstrated by solving molecular structures of protein complexes is a desirable but not a requirement.

Thrive

Some of the vast rewards of working here

As we work to develop treatments that take care of others, so we work to care for our teammates’ professional and personal growth and well-being.

• Full support and career-development resources to expand your skills, enhance your expertise, and improve your potential along your career journey
• A diverse and inclusive community of belonging, where teammates are empowered to bring ideas to the table and act
• Generous Total Rewards Plan—comprising health, finance and wealth, work/life balance, and career benefits—with compensation and benefits rated above 4 stars (out of 5) on Glassdoor

Apply now

for a career that defies imagination

Objects in your future are closer than they appear. Join us.

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