Scientist III, Bioinformatics

Requisition ID: 131183BR

Thermo Fisher Scientific Inc. is the world leader in serving science, with annual revenue exceeding $25 billion. Our Mission is to enable our customers to make the world healthier, cleaner and safer. Whether our customers are accelerating life sciences research, solving complex analytical challenges, improving patient diagnostics and therapies or increasing productivity in their laboratories, we are here to support them.

US – South San Francisco, CA

Clinical Next-Generation Sequencing Division

The position is based in South San Francisco, CA and is part of the extended Bioinformatics team within the Clinical Next Generation Sequencing Division. The mission of this business unit is to develop next-generation sequencing based solutions to support research applications in oncology and other important unmet medical needs.

How will you make an impact?

The successful candidate will be part of a multi-disciplinary team responsible for developing and launching cutting edge applications for Ion Torrent Sequencing instruments to advance genomic research, especially in Oncology and personalized medicine. The candidate will prototype, adopt, improve, develop, optimize, perform training and documentation, and validate algorithms and analysis software to analyze DNA/RNA/cfDNA sequencing data for oncology, pharmacogenomics, metagenomics, Immuno-Oncology and other applications.

The candidate will intensively analyze data, troubleshoot, draw conclusions, and visualize, document, and present their conclusions. The candidate will work with project teams and software teams. The candidate will be expected to work in a fast paced, complex setting to hard deliverables in a collaborative environment.

We're seeking a highly skilled individual with experience analyzing data, building models, algorithms, and software for analysis of next-generation DNA sequencing. Critical thinking, determination to succeed, the willingness and courage to push the boundaries on the possible and the drive to deliver are key attributes.

If you are a motivated and innovative bioinformatics scientist seeking to advance your career in these fields, we would like to invite you to join our NGS R&D Bioinformatics team in South San Francisco, CA.

What will you do?

• Your primary responsibility is contributing to development and validation of state of the art targeted sequencing assays for multiple applications, especially Oncology and Immuno-Oncology, used in research and clinical research settings worldwide.

• Work closely with molecular biologists, product managers, program managers, other bioinformatics colleagues, and software engineers to build high quality products.

• Contribute to solutions driving easy, automated analysis of human genetic variation obtained by high-throughput sequencing; develop algorithms and applications for inferring biological knowledge from millions of short reads, and optimize and validate application software.

• Perform analyses such as variant discovery, variant calling, CNV detection, and fusion calling. Interpret analyses, summarize results, and share findings with appropriate teams.

• Develop prototypes quickly, integrate these methods into production software, and collaborate with key internal and external groups.

You will remain up to date with the latest developments in in algorithms for analysis of next-generation sequencing and applications of sequencing, especially for personalized medicine and human health. You may engage with collaborators or users, and you may attend and present at scientific meetings as appropriate.

How will you get here?

Education

PhD in computer science, computational biology, biostatistics, bioinformatics, computer science or similar (MS considered for the candidate with the right experience).

Experience

• A background in DNA sequencing technologies, bioinformatics, genetics, biology.

• Demonstration of rapid prototyping of bioinformatics tools, leading to development of production code that is robust, fast, and highly accurate is strongly preferred.

• 1-5 years of relevant work experience. Equivalent post-doc or PhD experience is considered.

• Hands-on experience in developing bioinformatics analysis methods/algorithms development/scientific computing is strongly preferred.

• Strong programming experience on a UNIX platform in at least one programming language such as Python, Java, or similar.

• Experience with Matlab or R is desired.

Knowledge, Skills, Abilities

• Good understanding of Immunology, B cell and T cell malignancies is advantageous.

• Ability to engage in clear written and oral communication.

• Excellent problem solver, analytic thinker and quick learner

• Familiarity with common bioinformatics tools, high performance computing and understanding of assay design are all highly advantageous.

• Strong understanding of Bayesian statistics/Machine learning/Data science concepts is desired.

Our global team of more than 75,000 colleagues delivers an unrivaled combination of innovative technologies, purchasing convenience and pharmaceutical services through our industry-leading brands, including Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific, Unity Lab Services and Patheon. For more information, please visit www.thermofisher.com.

Thermo Fisher Scientific is an EEO/Affirmative Action Employer and does not discriminate on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability or any other legally protected status.