Career Category

Job Description

HOW MIGHT YOU DEFY IMAGINATION?

You’ve earned your degree. How will you use that achievement to reach your goals? Do more with the knowledge you’ve worked hard to acquire and the passion you already have. At Amgen, our shared mission—to serve patients—drives all that we do. It is key to our becoming one of the world’s leading biotechnology companies, reaching over 10 million patients worldwide. Become the professional you are meant to be in this meaningful role.

Scientist – Lysosomal Protein Degradation

Live

What you will do

Let’s do this. Let’s change the world. In this vital role you will be a part of Amgen’s Induced Proximity Platform (IPP). The IPP is charged with developing Amgen’s newest drug modalities that leverage proximity biology to tackle the undruggable genome. Examples include Targeted Protein Degradation modalities such as PROTACs and molecular GLUEs. The IPP is seeking a creative, emerging scientific leader to discover and develop novel therapies for cancer and other therapeutic areas leveraging the cellular degradation machinery, including lysosomes.

Primary Responsibilities:

• Develop lysosomal degradation modalities to impact challenging targets across multiple therapeutic areas, including oncology and immuno-oncology.
• The IPP takes innovative, cross-discipline approaches that leverage native cellular mechanisms to tackle the toughest targets.
• Lead a project to support discovery and development of novel lysosome-mediated protein degradation therapeutic modalities.
• Set project goals and timelines, design, perform and analyze experiments, interact with team members across different departments and research sites, and communicate and present data to department leadership.
• Inform departmental goals and strategy and will represent the department in various cross-functional activities including academic collaborations, external research evaluations, project teams, and scientific committees.
• Be expected to contribute to the scientific community through conference presentations and impactful publications.

Win

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The qualified professional we seek is a Scientist with these qualifications.

Basic Qualifications

Doctorate degree OR

Master’s degree and 4 years of relevant scientific experience OR

Bachelor’s degree and 6 years of relevant scientific experience

Preferred Qualifications

• Broad knowledge of cell and molecular biology with demonstrated research eminence through first author publications in top journals
• Deep knowledge of endosomal protein trafficking and lysosomal biology
• Research experience, including postdoctoral training, with biochemical, biophysical, molecular and cellular techniques, including enzyme and cell assay development, characterization of protein modification and turnover, and mechanistic studies of enzymes
• Excellent organizational, interpersonal and communication skills
• Flexibility to work in teams to achieve changing project goals and meet timelines

Thrive

Some of the vast rewards of working here

As we work to develop treatments that take care of others, so we work to care for our teammates’ professional and personal growth and well-being.

• Full support and career-development resources to expand your skills, enhance your expertise, and maximize your potential along your career journey
• A diverse and inclusive community of belonging, where teammates are empowered to bring ideas to the table and act
• Generous Total Rewards Plan—comprising health, finance and wealth, work/life balance, and career benefits—with compensation and benefits rated above 4 stars (out of 5) on Glassdoor

Apply now

for a career that defies imagination

Objects in your future are closer than they appear. Join us.

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Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

Amgen requires all staff in the United States and Puerto Rico to be vaccinated from COVID 19 as a condition of employment. In accordance with applicable law, Amgen will provide reasonable accommodations to staff members who qualify on the basis of a medical reason or a sincerely held religious belief, practice, or observance. Such accommodation may not pose an undue hardship to Amgen, its operations, or its staff.