Career Category

Scientific

Job Description

Amgen is a leading global biotechnology company, with a mission to serve patients around the world. As a science-based, patient-focused organization, we discover and develop innovative therapies to treat serious illnesses. Our medicines have made a dramatic difference in the lives of millions. To underpin our commitment to serve patients, Amgen is hiring in the Department of Protein Technologies, Biologics, at our Research and Development facility in South San Francisco, CA (ASF).

We are looking for a highly motivated and hardworking mammalian expression specialist to join the ASF Protein Technologies group. This laboratory provides comprehensive molecular cloning, protein expression, purification and analytics support for the Amgen pipeline. Amongst the responsibilities will be producing complex multi-specific antibody-like molecules for bioassays and in vivo studies, protein immunogens for therapeutic antibody discovery, and protein reagents which support clinical programs.

Responsibilities

• Work within a team of mammalian expression staff and interact with colleagues in protein engineering, molecular biology and protein biochemistry groups to deliver diverse protein reagents for research programs
• Using transient and stable expression methods, express a wide variety of protein classes; use analytical methods such as Vi-Cell, SDS-PAGE, Octet
• Use knowledge in cell biology and state-of-art expression systems to enhance team’s technical capabilities
• Drive engineering of CHO and HEK 293 cell lines, including the use of genome editing technologies (e.g. CRISPR/Cas9), to increase success with diverse protein classes
• Independently plan detailed procedures for projects including timelines and methods; analyze and interpret scientific data; provide regular updates about project results; document experiments in lab notebooks and LIMS; multi-task with focus on detail in fast-paced environment
• Collaborate with other Amgen Departments such as PKDM and Therapeutic Areas to advance therapeutic programs

Basic Qualifications

• Doctorate degree

Or

• Master’s degree and 4 years of scientific experience

Or

• Bachelor's degree and 6 years of scientific experience

Preferred Qualifications

• Ph.D. degree with a focus on molecular biology or cell biology with strong protein expression component
• Ph.D. and postdoc from a leading institution or biotechnology company
• Biotech/pharma industry experience with emphasis on recombinant protein expression and production, especially with common mammalian transient and stable platforms as well as production in WAVE reactors or other disposable bioreactor technologies.
• Strong knowledge of cell biology, expression construct design, cell line engineering and expression strategies for broad classes of proteins including mAb, bispecific antibodies, immunogens, and membrane proteins.
• Strong knowledge of expression host cell line engineering methods, including genome editing methods (e.g. CRISPR/Cas9), to enhance recombinant protein production and quality
• A track record of productivity, effective verbal and written communication and interpersonal skills, as well as the ability to work in a fast-paced team environment
• Independent critical thinking and scientific achievement in research, exemplified by publications, conference presentations or generation of intellectual property.

Join Us

If you're seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you'll find it at Amgen.

Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance.​

Join Us

If you're seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you'll find it at Amgen.

Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance.