Senior Scientist – Experienced analytical scientist, On Market Support, Chemical Development

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Location: Macclesfield

Competitive Salary & Benefits

Date Posted: 08.09.21

Be empowered to be innovative and creative where difference is valued

Join a place built on innovation and creativity! Where different views and perspectives are welcomed and valued. An environment that champions inclusion, and teams that reflect the diversity of the communities that we serve.

Pharmaceutical Technology and Development (PT&D) are the bridge, which turns brilliant science into actual medicines that help millions of people. We work across the entire value chain, crafting and delivering active ingredients, formulations and devices required to support new medicines – from supplies for use in early toxicology studies and clinical trials to developing the technology to ensure drugs can be scaled up for commercial manufacture.

We are currently recruiting for an experienced Senior Scientist to join our multi-skilled On-Market support group within Chemical Development!

In Chemical Development, we are dedicated to the lifecycle management of commercial active pharmaceutical ingredients (API) at AstraZeneca. Our drivers are to maintain continuity of supply, ensure license to operate and continue to deliver business value through optimisation of manufacturing processes and supply chain design. AstraZeneca currently manufactures a high percentage of API externally at Contract Manufacturing Organisations (CMOs).

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What you’ll do

As a Senior Scientist, you will be responsible for supporting our analytical technical contribution to maintain and optimise supply for one or more AstraZeneca commercial products meeting cost, quality and environmental targets for our customers. This includes:

• Authoring the CMC components of regulatory submissions and preparation of successful query responses

• Providing expert technical input to change control and improvement activities at CMOs and internal AZ API manufacturing sites, linking understanding to assess the impact of changes on control strategy and analytical measurements

• Supporting (CMOs) to optimally establish improvements to a manufacturing process and analytical aspects of control strategy increase manufacturing robustness, reduce analytical contributions to process variability and decrease environment impact

• Representing Chemical Development as lead analyst on CMC Project delivery teams to ensure compliance/license to operate, security of supply and supporting improvements and changes to the analytical methods and manufacturing process

• Executing or providing support and technical direction for any technical/experimental work required during investigation and definition of corrective and preventative actions

• Identifying and solving potential issues, and acting as an interface between departments

• Contributing to the development of the On Market Strategy to support AZ current and future portfolio, defining, and delivering continuous improvement plans

All these activities will have a significant impact on the speed, quality, cost and environment impact of the AZ commercial portfolio, the overall success of the Supply Chain as well as ensuring the commercial viability and reducing carbon footprint of the medicine.

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What you’ll need

• BSc/PhD level education in a relevant discipline and a number of year’s experience working within a Research & Development or Quality control Manufacturing environment, within the pharmaceutical industry

• A good understanding of the overall drug development process from discovery through to launch

• Experience of technical supervision and leading small teams of people or scientific projects.

• A specialist in related analytical areas or techniques with the ability to maintain that knowledge in order to provide expert advice

• A thorough understanding of the principles and management of SHE and cGMP

• Significant experience of delivering CMC content or contributions to regulatory filings throughout the life cycle of process or formulation analytical development, in the pharmaceutical industry

• An understanding of key analytical techniques, including NMR, chromatography and mass spectrometry

Skills & Capabilities

• Ability to think and operate across functional boundaries, challenge the norm and seek opportunities for business improvement

• Ability to analyse and interpret sophisticated situations and provide clear strategic directions for others

• Excellent communication and strategic influencing skills across interfaces of discipline, culture, and expertise both internally and externally

• Experience and skilled at facilitation at all levels

• Proven problem solver with in depth technical skills

• Proficiency in the use of statistics to understand data

• Experience of supporting commercial manufacture and working with contractors

• Experience of late stage development or commercial supply with a background in an analytical skill group

At AstraZeneca, we 're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learning, growth and development.

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So what’s next?

Please note applications should include your current CV and cover letter which details your key areas of strength / development and why you should be considered for the role. We welcome your application by 21st September 2021.

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Closing date: 21st September 2021

Where can I find out more?

Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/

Follow AstraZeneca on Facebook https://www.facebook.com/astrazenecacareers/

Follow AstraZeneca on Instagram https://www.instagram.com/astrazeneca_careers/?hl=en

Date Posted

Closing Date

AstraZeneca embraces diversity and equality of opportunity.  We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills.  We believe that the more inclusive we are, the better our work will be.  We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics.  We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.