Career Category

Research

Job Description

HOW MIGHT YOU DEFY IMAGINATION?

You’ve earned your degree. How will you use that achievement to reach your goals? Do more with the knowledge you’ve worked hard to acquire and the passion you already have. At Amgen, our shared mission—to serve patients—drives all that we do. It is key to our becoming one of the world’s leading biotechnology companies, reaching over 10 million patients worldwide. Become the professional you are meant to be in this meaningful role.

Senior Associate Scientist – Cell-based Assay

Live

What you will do

Let’s do this. Let’s change the world. In this vital role you will be a part of the Therapeutic Discovery organization joining the Discovery Technologies department in support of Amgen’s small molecule drug discovery pipeline.

Position responsibilities include:

• The development and optimization of novel cell-based assays ensure successful implementation and routine application of these assays to support HTS, lead optimization, and mechanism-of-action studies for promising therapeutic targets
• Design and implement laboratory experiments, generate and interpret data supporting the successful development of new assays and test the biological effects of therapeutic agents
• Learn, apply, and incorporate automation solutions during assay development, assay troubleshooting, mechanism-of-action studies, data analysis, and reporting
• Investigate, identify, develop, and optimize new methods/techniques to generate reliable and reproducible data promptly
• Semi-independently plan and implement experiments, and adapt readily to changing project needs
• Maintain proficiency with the latest scientific literature and rationale surrounding drug targets and be an active contributor to the interpretation of results in group discussions

Win

What we expect of you

We are all different, yet we all use our outstanding contributions to serve patients. The qualified professional we seek is a bench scientist with these qualifications.

Basic Qualifications:

Master’s degree and 3 years of Scientific experience

Or

Bachelor’s degree and 5 years of Scientific experience

Preferred Qualifications

• PhD degree or a Master’s degree with 4+ years postgraduate experience in cell and/or molecular biology or closely related subject area
• Experience working as part of a multi-disciplinary team in a biopharmaceutical setting
• Strong scientific foundation in the understanding and implementation of a wide range of cell-based assays and readouts (e.g., TR-FRET, BRET, PCA, AlphaLISA, MSD, HCS, luminescence and fluorescence-based reporter and/or label-free assays)
• Broad experience and expertise in molecular reagent generation and cell line engineering using gene editing approaches (CRISPR) as well as development and implementation of novel cellular target engagement, activity, and PPI assays (e.g., immunoassays, second messenger generation, ion flux, reporter, protein stability, PPI (splitNanoLuc, splitFAST, splitβ-gal), gene activation, cellular imaging)
• Experience with cell characterization and analytical techniques such as DNA sequencing, RT-qPCR and protein
• expression as well as expertise with phenotypic and functional characterization of immortalized or primary cells
• Established capabilities in setting-up and operation of multimode plate readers (e.g., FLIPR,
• EnVision, ViewLux, PHERAstar) and automated liquid handlers (e.g., Bravo, Echo, Tempest, BlueWasher) in the development of 384- and/or 1536-well microtiter plate assays
• Familiarity with software and statistical platforms for the analysis of large data sets (e.g., Screener, Spotfire)

Thrive

Some of the vast rewards of working here

As we work to develop treatments that take care of others, we also work to care for our teammates’ professional and personal growth and well-being.

• Full support and career-development resources to expand your skills, enhance your expertise, and increase your potential along your career journey
• A diverse and inclusive community of belonging, where teammates are empowered to bring ideas to the table and act
• Generous Total Rewards Plan—comprising health, finance and wealth, work/life balance, and career benefits—with compensation and benefits rated above 4 stars (out of 5) on Glassdoor

Apply now

for a career that defies imagination

Objects in your future are closer than they appear. Join us.

careers.amgen.com

Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance.