Career Category

Scientific

Job Description

HOW MIGHT YOU DEFY IMAGINATION?

You’ve earned your degree. How will you use that achievement to reach your goals? Do more with the knowledge you’ve worked hard to acquire and the passion you already have. At Amgen, our shared mission—to serve patients—drives all that we do. It is key to our becoming one of the world’s leading biotechnology companies, reaching over 10 million patients worldwide. Become the professional you are meant to be in this meaningful role.

Sr. Associate Scientist - Cardiometabolic Disorders

Live

What you will do

Let’s do this. Let’s change the world. The Cardiometabolic Disorders Therapeutic Area at Amgen-South San Francisco is seeking a Senior Associate Scientist or Scientist to join our dynamic team and contribute to the discovery of novel targets and drug development.

Position Responsibilities

This position is laboratory-based, requires proficient experimental skills and an aptitude to work effectively in an integrated environment. The ideal candidate is an expert in in vitro pharmacology with extensive experience in the design, validation and execution of cell-based or biochemical assays to evaluate small and large molecules. A proven track record as demonstrated through high-impact scientific publications, patents or IND-filing is essential. Highly motivated candidates with hands-on, experience in specialized domains of molecular and cellular biology with basic animal handling skills are encouraged to apply.

Win

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The qualified professional we seek is a scientist with these qualifications.

Basic Qualifications

Ph.D and equivalent advanced degree

OR Master’s degree and 3 years of scientific experience

OR Bachelor’s degree and 5 years of scientific experience

Preferred Qualifications

• For Sr Associate Scientist, M.S or Ph.D in biomedical sciences with relevant hands-on experience in cardiometabolic drug discovery. For Scientist, Ph.D in pharmacological sciences with substantial (>3yrs) postdoctoral training is necessary. Strong considerations will be given to applicants with industry work experience or training.

• Broad understanding of GPCR/receptor signaling, ion channel biology, cardiovascular diseases (HF, arrhythmia), autoimmunity, human genetics will be highly meritorious.
• Strong assay (TR-FRET, HTRF, FP, BRET, luminescence, ALPHA, kinase, epigenetic, cell-reporters, FACS, immunoassays, biomarker) development experience is required.
• General cell culture and gene manipulation, including CRISPRi, CRISPRa, siRNA, shRNA, mod-mRNA and viral transduction.
• General molecular biology and biochemical techniques including protein, mRNA detection via immunoblotting, immunocytochemistry, RT-qPCR, immunoprecipitation and ELISA.
• Expertise in maintaining and differentiating human iPSC and genetic engineering of clones (CRISPR/TALEN) will be highly preferred.
• Experience in various biochemical assays (protein-protein interactions, enzymatic turnover, probe displacement, radioligand binding) will be a plus
• Experience in safe handling of human specimens or an ability to perform in vivo or ex vivo studies using rodent models of heart disease (Langendorff, TAC, LAD-ligation, AngII/PE pumps) will also be highly advantageous.
• Meticulous and detailed experimental book-keeping skills are a must.
• Ability to synthesize technical information from published literature and present clear summaries of results to guide go/no-go decisions.
• Self-motivated, quick learner with excellent communication/analytical skills, able to adhere to strict compliance policies and work efficiently in a cross-functional team.
• Ability to manage competing priorities or projects and meet deadlines
• A passion for science and avid problem-solving skills as demonstrated by publications, patents or IND applications.

Thrive

Some of the vast rewards of working here

As we work to develop treatments that take care of others, so we work to care for our teammates’ professional and personal growth and well-being.

• Full support and career-development resources to expand your skills, enhance your expertise, and maximize your potential along your career journey
• A diverse and inclusive community of belonging, where teammates are empowered to bring ideas to the table and act
• Generous Total Rewards Plan—comprising health, finance and wealth, work/life balance, and career benefits—with compensation and benefits rated above 4 stars (out of 5) on Glassdoor

Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

Amgen requires all staff in the United States and Puerto Rico to be vaccinated from COVID 19 as a condition of employment. In accordance with applicable law, Amgen will provide reasonable accommodations to staff members who qualify on the basis of a medical reason or a sincerely held religious belief, practice, or observance. Such accommodation may not pose an undue hardship to Amgen, its operations, or its staff.

Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance.