Career Category

Scientific

Job Description

HOW MIGHT YOU DEFY IMAGINATION?

If you feel like you’re part of something bigger, it’s because you are. At Amgen, our shared mission—to serve patients—drives all that we do. It is key to our becoming one of the world’s leading biotechnology companies. We are global collaborators who achieve together—researching, manufacturing, and delivering ever-better products that reach over 10 million patients worldwide. It’s time for a career you can be proud of. Join us.

Principal Scientist – PKDM, Modeling and Simulation

Live

What you will do

Let’s do this. Let’s change the world. In this vital role you will work directly within various Amgen project teams to apply quantitative solutions in the development of novel therapeutics through various activities including target/compound evaluation, design of preclinical studies, assessment of preclinical and clinical exposure relationships (target engagement, pharmacodynamic, and efficacy), execution of translational strategies, and contribute clinical study design.

Responsibilities:

• Design and implement PKPD and mechanistic modeling activities in the preclinical space for drug discovery and development.
• Prepare reports and team presentations, collaborate in multidisciplinary team settings
• Requires critical and strategic thinking, excellent communication and teamwork skills and passion for using quantitative principles to guide the efficient development of drugs to help patients in need.
• This position also provides the opportunity to pursue scientific inquiries into PK/PD relationship of small and large molecule biotherapeutics, authoring of scientific reports, scientific papers and presentations at scientific meetings.

Win

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The Scientist professional we seek is a leader with these qualifications.

Basic Qualifications:

• Doctorate degree and 2 years of experience on applying quantitative PKPD principles to drug development or other relevant experience
• Master’s degree and 5 years of experience on applying quantitative PKPD principles to drug development or other relevant experience or
• Bachelor’s degree and 7 years of experience on applying quantitative PKPD principles to drug development or other relevant experience

Preferred Qualifications:

• Doctorate (Ph.D.) in chemical or biomedical engineering; applied mathematics; quantitative pharmaceutical sciences or a related field with 5+ years of experience in drug discovery and development
• Proven track record applying systems modeling and simulation approaches in biological systems and/or drug development to support strategic decision making
• Proficiency with systems modeling approaches such as differential equations, nonlinear mixed effects modeling, logic, stochastic, agent-based, or other advanced mechanistic modeling approaches is essential
• Hands-on experience with relevant software or programming languages (e.g., Simbiology, MATLAB, R, or C) is essential.
• Highly motivated, self-driven, can perform well both working independently and in team settings
• Excellent oral and written communication skills

Thrive

What you can expect of us

As we work to develop treatments that take care of others, so we work to care for our teammates’ professional and personal growth and well-being.

• Vast opportunities to learn and move up and across our global organization
• Diverse and inclusive community of belonging, where teammates are empowered to bring ideas to the table and act
• Generous Total Rewards Plan comprising health, finance and wealth, work/life balance, and career benefits

Apply now

for a career that defies imagination

In our quest to serve patients above all else, Amgen is the first to imagine, and the last to doubt. Join us.

careers.amgen.com

Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance.