Career Category

Research

Job Description

The Genome Analysis Unit (GAU) is seeking a talented computational biologist to join our team and further our mission of making biological discoveries that accelerate development within Discovery Research and Preclinical Development at Amgen. The position focuses on the application of bioinformatics expertise to the analysis and interpretation of large datasets to support ongoing drug development projects in close collaboration with project teams. These datasets include in vitro and in vivo assay results, RNA expression, genetics, and high value public resources. Additionally, the role will involve the creation of novel algorithms and analytical approaches that can be used to both identify new drug targets as well as predict the safety profile of our molecules and thus increase clinical success rates.

Responsibilities

Apply advanced techniques in bioinformatics, statistical analysis, and programming to biological problems across a wide range of human disease and drug safety areas at Amgen

Work with large internal and external biological data sets including Next Generation Sequencing (NGS) data (e.g. RNA-Seq, scRNA-Seq, WGS)

Perform analyses on MHC/peptide prediction based on HLA types and protein sequences. Perform TCR sequence analyses to modeling TCR/MHC/Peptide interaction

Interface directly with project teams and key stakeholders within Amgen to ensure the appropriate and timely inclusion of relevant datasets

Integrate work tightly with wet lab efforts within the GAU, Discovery Research and CBSS focused on predictive safety and target validation

Represent group internally and externally through presentations, publications, networks, collaborations and conferences to promote approaches and raise the profile of work within the team

Basic Qualifications

Doctorate degree or Doctorate degree with 2 years of experience

OR

Master’s degree and 6 years of scientific experience

OR

Bachelor’s degree and 8 years of scientific experience

Preferred Qualifications

Advanced degree in Bioinformatics, Biostatistics, Computer Science, Genomics

Hands-on experience in the fields of bioinformatics and genomics including working with various public and proprietary data

repositories (e.g., TCGA, GTEx, dbGaP, Ensembl, UCSC genome browser, Array Studio), bioinformatics tools (e.g., BLAST,

GATK, Cell Ranger, samtools, VEP), and statistical environments (e.g., R, S+, Matlab)

Experience with manipulation, interpretation, and innovative analysis (e.g. novel algorithm development) of large biological datasets, including single-cell sequencing data

Research experience in the field of immuno-oncology

Experience with MHC/peptide prediction and TCR sequence analyses and modeling is preferred

Proficient in programming (e.g., Python, Java, C/C++) and working in a Unix/Linux environment; ability to develop customized bioinformatics tools

At Amgen, our mission is serving patients. Our staff are dedicated to pushing the boundaries of science to transform medicine and turn the tide on serious illnesses. Central to achieving this mission is our “people-first” philosophy. We recruit the best talent, build an environment that facilitates career growth, and provide staff with the opportunity to make significant contributions for patients and our business.

Consistent with our core leadership value of “Develops the Best Team,” we are seeking leaders that prioritize the development of talent. As a manager, your first priority and primary role is to accelerate the performance and development of your team. We expect managers to exemplify strong leadership and champion self-awareness and career development. Ways that you will display your leadership acumen in this role include:

• Mentoring, coaching, and developing staff to build highly-skilled, diverse, and inclusive teams
• Fostering a positive and respectful work environment that encourages staff retention and motivates individuals to work toward common goals and priorities
• Ensuring that staff understand how their efforts and contributions make a meaningful impact to the business
• Growing core skills and capabilities among staff, particularly in learning agility, problem solving, strategic and creative thinking, flexibility, resilience, effective communication, prioritization, delivery of results, and continuous improvement
• Making accurate evaluations of your team's skills and competencies and providing timely and respectful feedback, including direct delivery of difficult messages
• Developing an understanding of your team's career objectives and serve as a thought-partner in their career development plans

Amgen focuses on areas of high unmet medical need and leverages its expertise to strive for solutions that improve health outcomes and dramatically improve people’s lives. Our culture is what makes Amgen a special place to work. We have a powerful shared purpose around our mission – to serve patients. We respect one another, recognize contributions, and have embedded collaboration, trust, empowerment and inclusion in all that we do.

Join Us

If you're seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you'll find it at Amgen.

Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance.