About AbbVie AbbVie’s mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people’s lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women’s health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on Twitter, Facebook, Instagram, YouTube and LinkedIn. Since 2013, AbbVie has expanded its commitment to the San Francisco Bay Area with the consolidation of three Bay Area facilities to a new Bay Area headquarters in South San Francisco. AbbVie employees in the Bay Area drive AbbVie’s research-based, innovation driven missions in healthcare. Specifically, Bay Area employees bring deep scientific expertise and commercial excellence to advance cancer care. Current oncology areas of focus include immuno-oncology, tumor targeting, tumor dependency and precision medicine. With facilities positioned in the heart of the biotechnology industry, we are able to collaborate with the best and brightest minds in oncology. Oncology is a key therapeutic area for AbbVie, with a portfolio consisting of three marketed products — Imbruvica, Venclexta, and Empliciti — and a pipeline containing multiple promising new molecules that are being studied in nearly 200 clinical trials in 19 different types of cancer. AbbVie is expanding its oncology hub on the West Coast, with three sites in the San Francisco Bay Area (Redwood City, South San Francisco, and Sunnyvale) moving into a brand-new site in South San Francisco and focusing on the discovery and development of novel oncology therapies. More than 1,000 AbbVie scientists, clinicians, and product developers with strong entrepreneurial roots work across these three sites. They combine their expertise in immuno-oncology, stem cells, and cell-signaling with their knowledge of bispecific antibodies, antibody-drug conjugates (ADCs), and covalent-inhibitor technologies to discover and develop novel cancer treatments. This position is based at AbbVie’s new South San Francisco, CA location. We are hiring a Senior Scientist II to join the In Vivo Pharmacology Department in Oncology Discovery at Abbvie. The Senior Scientist II will conduct tumor efficacy and PK/PD studies, develop novel preclinical models and provide pharmacology support to innovative cancer drug development. The scientist will report to Director, Preclinical Pharmacology and work collaboratively in a project team setting with biology, medicinal chemistry and DMPK scientists, providing in vivo proof-of-principle for target discovery and validation, formulating and executing efficient in vivo structure activity relationship strategy and advancing oncology programs to clinical development. General Position Summary/Purpose: Provide preclinical Pharmacology support to Abbvie oncology drug discovery and development projects in targeted therapeutics and immuno-oncology. Conceive and implement novel experimental approaches to tumor model development, efficacy/PK/PD, in vivo mechanism-of-action investigation, target discovery and validation, disease mechanisms, resistance biology, and tumor microenvironment interaction in support of drug discovery and development. Investigate, develop, validate or optimize existing and new methods/models to solve project related scientific problems. Work closely with scientists in biology, medicinal chemistry, DMPK, translational medicine while reporting to Director, Preclinical Pharmacology. Generate efficacy and PD data to support preclinical development of drug candidates and regulatory submissions. Develop productive collaborations and communications with other groups across scientific disciplines. Design and conduct tumor efficacy, imaging and PD studies to support in vivo POC, SAR and IND submission. Provide Pharmacology knowledge and strategy within project team structure and present/report analyses of in vivo studies. Understand and adhere to IACUC protocols regarding animal welfare and handling. Cell culture, sorting and genetic manipulation of cells to support efficacy studies and tumor model development. Conduct ex vivo assays such as multi-color FACS, MSD, WES and Luminex to understand MOA of in vivo studies. Develop novel preclinical models such as genetically modified mouse models, orthotopic tumor models, adoptive transfer and humanized models Improve existing Pharmacology workflows, data visualization tools, and work across discovery teams to integrate efficient workflows for cross-functional analyses and endpoints. Thinking critically and innovatively. Commitment to scientific rigor, high data quality and careful documentation. Self-motivated, possess strong problem solving and organizational skills. Ability to manage multiple responsibilities, adapt to changing priorities and meet deadlines in a fast-paced environment. Excellent written and verbal communication skills. Flexibility and motivation to learn techniques and accomplish goals outside those stated above. Qualifications PhD in pharmacology, cancer biology, cell biology, immunology, or related field with 5+ years of drug development experience in a pharmaceutical or biotech industry setting, and a solid publication record. A strong background in pharmacology, cancer biology or immunology. Demonstrated aptitude for innovation using novel/emerging technologies. Experience in designing and interpreting IND-enabling in vivo PK/PD/efficacy studies and report writing Proficient hands-on experience with mouse tumor models. Experience and knowledge with genetically engineered mouse models and orthotopic tumor models Mouse surgery and in vivo imaging experience is desired. Technical experience in flow cytometry, primary cell culture, tissue processing, as well as other standard molecular and cellular biology assays (MSD, ELISA, Wes, etc.). Must be proactive and able to work effectively on multiple projects in a fast-paced, dynamic environment. Strong written and verbal communication skills. Demonstrated ability to work independently and collaboratively to design, execute and interpret experiments to answer scientific questions (desired). Significant Work Activities N/A Travel No Job Type Experienced Schedule Full-time Job Level Code M Equal Employment Opportunity At AbbVie, we value bringing together individuals from diverse backgrounds to develop new and innovative solutions for patients. As an equal opportunity employer we do not discriminate on the basis of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information gender identity or expression, sexual orientation, marital status, protected veteran status, or any other legally protected characteristic.