Do you have expertise in, and a passion for Oncology Translational Medicine? would you like to apply your expertise to impact an industry-leading portfolio of programs; from early clinical development of novel therapeutics through post-marketing opportunities that support approved targeted therapies in a company that follows the science and turns ideas into life changing medicines? Then AstraZeneca might be the one for you!

About AstraZeneca

AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development and commercialisation of prescription medicines for some of the world’s most serious diseases. But we’re more than one of the world’s leading pharmaceutical companies.

Site description

Welcome to our Chesterford Research Park, one of over 400 sites here at AstraZeneca, providing a collaborative environment where everyone feels comfortable and able to be themselves is at the core of AstraZeneca’s priorities, it’s important to us that you bring your full self to work every day. To help you maintain your best self, here’s a sneak peek into some of the things this site provides for you…high quality office facilities accommodating teams from our Oncology, BioPharmaceuticals R&D Organisations. Restaurant and bar facilities within the park along with space for recreational walks and jogging paths. The park hosts a health and fitness centre and provides coach and shuttle bus services to Cambridge City centre, easily accessible via regular running public transport, you can also park at the site.

Business area

From diagnosis to later stage development, we’re laser-focused on leading the way forward to create solutions that transform lives. We are focused on identifying and treating patients earlier, where there is greater curative potential. With the greatest number of early stage cancer trials in the industry, we are getting closer to finding cures every day.

It is the breadth and strength of our innovative pipeline that offers both security and stability. And with the goal to deliver 6 new molecular entities by 2025, it’s up to each of us to keep pushing our industry-leading Oncology pipeline forward and build the future

What you’ll do

We are seeking a Senior Scientist to join the Oncology Translational Medicine group in our Clinical Translational Laboratory. You will be based in a world-class centre for discovery and development of innovative cancer medicines; based at the heart of the Cambridge UK biomedical research community, at the forefront of the evolution of translational science for the global oncology group at AstraZeneca. You will have the opportunity to impact an industry-leading portfolio of programs from early clinical development of novel therapeutics through post-marketing opportunities that support approved targeted therapies.

• As a laboratory-based senior scientist your focus is to deliver biomarker data on clinical trial samples based on the best available science and technologies.

• You will be measuring target engagement reliably and quantifiably to advise clinical decisions for selecting therapeutically relevant doses and schedules.

• You will understand key cancer pathway interactions and feedback mechanisms in clinical samples to guide rational drug combinations.

• You will provide expert interpretation of the data, identifying innovative solutions to problems and putting forward plans for future biomarker assays.

• Generating disease linkage data to guide indication selection and targeted patient populations.

Essential for the role

• PhD or master’s degree with expertise in a relevant field.

• Experience in protein analysis and proteomics methods.

• Strong experience in molecular and cell biology, with experience in assay development for new biomarkers.

• Experience in working with peripheral blood and isolation of its components and/or on developing assays in peripheral blood mononuclear cells.

• Experience in cancer biology and peer-reviewed publications in the field of molecular cancer biology.

• Experience of conducting studies for Good Clinical Practice (GCP).

• Ability to lead from the bench in problem solving and the development of innovative solutions.

• Ability to collaborate with colleagues both within Translational Medicine and across multidisciplinary teams and able to work well within group environments.

Desirable for the role

• Experience in the pharmaceutical industry and the drug development process.

• Expertise in one or more AZ portfolio areas: DNA damage and repair, tumour drivers and resistance, hormone receptor signalling, epigenetics

Why AstraZeneca?

At AstraZeneca we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration, and always committed to lifelong learning, growth and development. We’re on an exciting journey to pioneer the future of healthcare.

So, what’s next?

• Are you already imagining yourself joining our team? Good, because we can’t wait to hear from you.

• Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have one seat available and we hope it’s yours.

• If you’re curious to know more then please reach out to Louise Bennett

Competitive salary package and benefits

Close Date: 27/09/2021

Where can I find out more?

Our Social Media,

Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/

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Date Posted

Closing Date

AstraZeneca embraces diversity and equality of opportunity.  We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills.  We believe that the more inclusive we are, the better our work will be.  We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics.  We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.