Career Category

Scientific

Job Description

Amgen’s Therapeutic Discovery organization is seeking an innovative collaborative Senior Scientist with demonstrated expertise in biologics drug discovery to join the protein engineering team within Protein Technologies. Protein Technologies produces key enabling reagents to support the early discovery of small and large molecule therapeutics and the development of ground breaking novel modalities. Protein engineering prosecutes on meaningful targets and tool antibodies/protein-based therapeutic modalities following the operational principle of design (structural analysis, computational design), build (cloning, protein expression, purification) and test (biophysical characterization). The Senior Scientist serves as Protein Technologies Lead for early stage therapeutic projects, works with partner functions to devise and operationalize reagent production strategies, drives scientific innovation in protein engineering through technology advancement and contributes to pipeline reagent production needs. Activities will be divided between hands-on lab work and project leadership with responsibilities including:

• Representing Protein Technologies as project team lead with partner functions to devise reagent production strategies.
• Expertly executing on protein engineering projects from construct design through protein production.
• Supporting structure-based design activities such as fusion protein construct design, complex immunogen design, protein stabilization and affinity modulation of protein/protein interactions.
• Expressing designed proteins.
• Continually evaluating and incorporating new technologies to support protein engineering and design.

Basic Qualifications

Ph.D. in Biochemistry, Biophysics, Chemistry, Molecular Biology or related discipline and 2 years scientific experience

OR

Master’s Degree and 5 years of scientific experience

OR

Bachelor’s Degree and 7 years of scientific experience

Preferred Qualifications

• Ph.D. and postdoc from a leading institution or biotechnology company and three or more years of related industry experience.
• A track record of scientific accomplishments and project leadership in biologics drug development as evidenced by peer-reviewed publications, patents or pipeline contributions.
• Strong desire to execute on and drive technical innovation in protein engineering.
• Expert knowledge of protein structure and structure/function relationships.
• Protein/antibody expression in mammalian and/or bacterial expression systems.
• Cell line engineering for production of difficult protein and multispecific antibodies.
• Protein modeling using Rosetta or a similar tools.
• Desire to be a phenomenal teammate in a multi-functional team environment.
• Ability to thrive and adapt in a dynamic environment.
• Strength in teamwork, negotiation and multitasking.

Join Us

If you're seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you'll find it at Amgen.

Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance.