Senior Scientist Job Description:

AstraZeneca has an opportunity for a Senior Scientist position within the Bioscience Metabolism group of the Cardiovascular, Renal, and Metabolism department (CVRM).  The successful candidate should have extensive hands-on in vivo pharmacology experience in rodent models of diabetes, obesity, and NASH as well as comprehensive background knowledge in metabolic and liver disease.   Expertise in working with a variety of drug modalities would be a plus, and ex vivo lab techniques including tissue gene expression, ELISAs, western blot analysis, etc. are required.   The successful candidate will drive experimental work, including the design, execution and interpretation of preclinical experimental data.   Additionally, the candidate will present results to group and project team meetings, and potentially at scientific conferences.  The ability to work well in a team environment, and to interact with departments outside of CVRM is essential for this position. 

Requirements:

Education:  Degree in a biological science field

Ph.D. and 3+ years of relevant experience (preferred), or MS and 10+ years of relevant experience or BS and 13+ years of relevant experience

Core responsibilities:

• Highly proficient in working with rodent models of NASH, diabetes, and obesity – hands-on expertise in animal handling, dosing (SC, IV, PO, and IM), and necropsy tissue collections (essential)

• Administration of CVRM therapeutic modalities to CVRM rodent models (essential)

• Independently execute ex vivo analysis of blood/tissue samples including qPCR gene expression, Western blots, and ELISAs (essential)

• Take part in all experimental work, including the design, analysis, and interpretation of data from these experiments (essential)

• Prepare and present scientific data to in vivo group and project team meetings (essential)

• Work in a cross-functional project team with the responsibility of making decisions and recommendations for the program in vivo pharmacology plans (essential).

• Maintain an understanding of the scientific basis of the CVRM project pipeline, sufficient to be able to successfully execute experiments needed to meet the requirements of the projects involved with (essential)

• Participate in collaborations related to specific projects (essential)

• Raise the scientific profile of CVRM externally through publishing data in peer-reviewed journals and by presenting at conferences (essential)

• Contribute to CVRM animal model work and/or development including areas of NASH, obesity, dyslipidemia, CV, and diabetic kidney disease (essential)

• Lead drug projects in the metabolism disease area. Propose and champion new targets and novel approaches for disease treatment (desirable)

• Execution of metabolism in vivo assays including GTTs, ITTs, and measurement food intake (desirable)

• Experience in surgical procedures is desirable

• Experience in the pharmaceutical industry desirable

Date Posted

Closing Date

AstraZeneca embraces diversity and equality of opportunity.  We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills.  We believe that the more inclusive we are, the better our work will be.  We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics.  We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.