Principal/Senior Statistician – Global Medical Affairs/Payer Biometrics

Location Cambridge, England, United Kingdom or Gothenburg, Sweden

Would you like to be a part of a group that is involved in playing a key role in getting medicines to patients?

At AstraZeneca, every one of our employees makes a difference to patient lives every day. Each and every one of us believes that science has the ability to change lives and that to deliver this takes many people with many skill sets. When we deliver a life-changing medicine, that success comes from the combined efforts of all of our people.

We are currently looking for a senior/principal statistician to work within our Global Medical Affairs and Payer Biometrics group which sits within Oncology Biometrics. The group serves a dual role. Firstly, providing statistical support and expertise for Global Medical Affairs interventional and Real World Evidence (RWE) studies, including developing design options and providing high quality decision support. Secondly, providing statistical support for the Global Oncology Payer Function via the application of quantitative skills to support decision-making processes and value demonstration, including contributing to Health Technology Assessment (HTA) submissions.

If you’re inspired by the possibilities of science to make a difference and ready to discover what you can do – join us

Main duties and responsibilities

The main duties and responsibilities of the role will include;

• Design and analysis of interventional and non-interventional studies (incl. sample size estimation and randomisation specification.) 
• Developing statistical analysis plans for complex studies and/or project deliveries.
• Contributing to protocols, clinical study reports, regulatory documents and manuscripts. 
• Providing support to the payer function for late stage oncology assets. Including post hoc analysis of clinical trial data to support development of cost effectiveness and budget impact models.
• Representing AstraZeneca to Health Authorities and Reimbursement & Payer Organizations for specific projects
• Analysis of published literature and RWE sources (e.g. network meta-analysis and synthetic control arms).
• Dependent on experience, mentoring of more junior staff and presenting at internal training seminars.

Desirable qualifications and experience:

The level of the position will be determined through the interview process where skills, experience and capabilities can be demonstrated and evaluated. Desirable qualifications and experience include:

• MSc or Ph.D. Statistics, Biostatistics, or Mathematics (containing a substantial mathematical component).
• Experience in drug development, study design, and data analysis and interpretation.  
• Publication experience and/or experience of presenting at external meetings (e.g. ISPOR, PSI)
• Programming expertise in R, WinBugs and/or SAS.
• Experience of reimbursement submissions in key markets (e.g. UK and Germany.).
• Regulatory submission experience in key markets (e.g. EU and USA.)  
• Application of indirect comparison methodology (e.g. Bayesian/Frequentist NMA and MAIC/STC methodologies).
• Experience of performing adjustment for treatment switching/cross-over within clinical trials (e.g. RPSFT and IPCW methodology.).

• Analysis of health utility data including mapping and value set application.
• Application of causal inference models to clinical trial and RWE data.
• Experience of working with RWE datasets and registries (e.g. Flatiron.).

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.

Next Steps – Apply today!

To be considered for this exciting opportunity, please complete your application on our website at your earliest convenience.

We would like to know more about you.

At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognising their potential. Join us on our journey of building a new kind of organisation to reset expectations of what a bio-pharmaceutical company can be. This means we’re opening new ways to work, pioneering cutting edge methods and bringing unexpected teams together. Interested? Come and join our journey.

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Date Posted

Closing Date

AstraZeneca embraces diversity and equality of opportunity.  We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills.  We believe that the more inclusive we are, the better our work will be.  We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics.  We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.