Team Manager – Process Chemistry

Location: Macclesfield, UK

Date Posted: 2nd September 2021

Make a more meaningful impact to patients’ lives around the globe

Here you’ll have the opportunity to make a meaningful difference to patients’ lives. With science at its heart, this is the place where breakthroughs born in the lab become transformative medicines – for the world’s most complex diseases. Answer unmet medical needs by pioneering the next wave of science, focusing on outcomes and shaping the patient ecosystem.

If you have the passion and the drive to accelerate growth and make people’s lives better – then this is the place for you!

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Business Area

Pharmaceutical Technology and Development (PT&D) is the bridge, which turns forward-thinking science into actual medicines that help millions of people. We work across the entire value chain, crafting and delivering active ingredients, formulations and devices required to support new medicines – from supplies for use in early toxicology studies and clinical trials, to developing the technology to ensure drugs can be scaled up for commercial manufacture and ultimately continuing to ensure that these medicines can be manufactured for supply to patients.

Within PT&D, in Chemical Development, we believe that nothing is impossible, and we are determined to push the boundaries of science to deliver medicines to our patients. We combine people’s deep technical knowledge and understanding with their talent and drive to design, develop and optimise synthetic routes that deliver the active pharmaceutical ingredients (API) of our medicines in a sustainable, commercially viable way.

We believe in innovation and continuous improvement, working closely with colleagues in academia and across industry, we apply the newest technologies and principles in the processes we develop.

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The Role

We are now looking for a Team Manager – Process Chemistry to join our team!

In this role you will contribute to the Chemical Development function in PT&D and will lead a team of 10-12 Process Chemists. The Process Chemistry Team is responsible for:

• Developing sustainable chemical routes and chemical processes for drug substance based on comprehensive process understanding

• Developing and implementing sustainability (with low carbon footprint) into drug substance manufacturing processes

• In conjunction with other skill groups, developing the overall control strategies to ensure the appropriate quality and robustness of clinical and commercial products according to current regulatory guidance

• Supporting manufacturing activities to supply materials for clinical studies

• Technology Transfer of manufacturing methods

• Authoring and reviewing of CMC documentation for clinical and marketing AstraZeneca product submissions

• Identification and exploitation of innovative science, cutting edge technology and future capabilities to improve drug substance manufacturing processes

• Securing Intellectual Property and freedom to operate

In addition the team acts as a source of expert guidance in the above areas for the chemistry skill group within chemical development.

All of these activities have a significant impact on the speed, quality and cost of the AstraZeneca development portfolio, the overall success of PT&D as well as ensuring the commercial viability of the medicine. The role, therefore, has a meaningful impact on both financial and reputational aspects of the business.

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What you’ll do

As Team Manager – Process Chemistry, you will;

• Coach direct reports, and others, for enhanced individual and team performance

• Ensure the delivery of SHE and cGMP compliance, ensuring that all work is carried out with regard to AstraZeneca and external regulatory policies and standard

• Set the team strategy and ensure the optimal delivery of the project portfolio within your area of responsibility

• Ensure work within your own project, and those outside of the team, meet required standards

• Build strong, collaborative relationships with Operations, Regulatory, Projects and Portfolio Management, Pharmaceutical Science, Supply Chain, at an operational level

• Enhance the reputation of the company in scientific circles by representing AstraZeneca, through external presentations, publications, membership of working parties and through academic collaborations

What you’ll need - Education, Qualifications, Skills and Experience

• A good understanding of the overall drug development process from discovery through to launch with an appreciation of how Pharmaceutical Development contributes to R&D and the broader business

• A graduate or PhD with significant business and industry experience

• A sufficient understanding in the disciplines in Process Chemistry in order to contribute to a world class Chemical Development organisation

• Experience or capability to lead and manage a team of scientists

• A thorough understanding of principles, applications and management of SHE and cGMP

• Good communication skills and evidence of strong operational relationships with customers

With our ground-breaking pipeline, the outlook is bright. Be proud to be part of a place that has achieved so much, yet is still moving forward. There’s no better time to join our global, growing enterprise as we lead the way for healthcare and society.

So what’s next?

Applications are welcome from 2nd September to 16th September August 2021.

Please include a Cover Letter detailing your suitability and motivations in applying for the role, together with your CV.

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Competitive salary and benefits

Where can I find out more?

Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/

Follow AstraZeneca on Facebook https://www.facebook.com/astrazenecacareers/

Follow AstraZeneca on Instagram https://www.instagram.com/astrazeneca_careers/?hl=en

Date Posted

Closing Date

AstraZeneca embraces diversity and equality of opportunity.  We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills.  We believe that the more inclusive we are, the better our work will be.  We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics.  We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.