Senior Research Scientists & Research Scientists – Cell Engineering

Location: Cambridge, UK

Salary: Competitive with excellent benefits

At AstraZeneca we turn ideas into life changing medicines. Working here means being results-oriented, thinking big and working together to make the impossible a reality.

We are looking for Research Scientists and Senior Research Scientists to work in our Cell Engineering team within AstraZeneca’s Discovery Sciences based in Cambridge, UK. These roles provide an exciting opportunity to join a vibrant environment passionate about the generation of cell models for target identification/validation and cascade development in drug discovery.

You will use state of the art editing methods to endogenously modify disease relevant cells to enable characterisation and perturbation of a variety of biological processes. As part of an innovative team you will work with our postdoc community, our global precise genome editing community and high-profile external collaborators to improve current CRISPR methods for use in preclinical model generation. You will maintain scientific excellence, presenting data to key stakeholders internally and at external conferences in addition to publishing in peer-reviewed journals.

In this role you will be embedded in AstraZeneca’s UK Discovery Biology department and join a community of scientists with broad technological expertise dedicated to drug discovery. They will become integral members of early drug discovery projects at AstraZeneca.

We need candidates who have the relevant knowledge, attention to detail and a passion for science. At AstraZeneca we work together to provide medicines that make a real difference in patient care. A place with an ambitious and collaborative culture, where you'll feel valued and rewarded for your ideas and contributions.

Essential Requirements

• Ph.D in cell biology, molecular biology or equivalent experience
• Proven experience in manipulation of cell lines
• Strong experimental design and problem-solving skills
• Scientific excellence as shown by previous work, publication history and references from scientific mentors
• Excellent team working, communication and networking skills with experience of interacting effectively across interfaces of discipline, culture and expertise.

Desirable Requirements

• Experience in Oncology signaling pathways
• Experience of CRISPR/Cas9, genome editing and stable cell engineering
• Experience in endogenous tagging
• Experience of cell-based assays and high content imaging to measure disease-relevant phenotypes
• Experience of NGS and NGS data analysis

How to Apply

Please apply online before midnight on 3rd November 2020.

Date Posted

Closing Date

AstraZeneca embraces diversity and equality of opportunity.  We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills.  We believe that the more inclusive we are, the better our work will be.  We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics.  We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.