Senior Research Scientists & Research Scientists – High Throughput Screening

Location: Alderley Park, Cheshire prior to relocation to Cambridge

Salary: Competitive with excellent benefits

At AstraZeneca we turn ideas into life changing medicines. Working here means being results-oriented, thinking big and working together to make the impossible a reality.

We are looking for Research Scientists and Senior Research Scientists to work in our Global High Throughput Screening (HTS) Centre based in Alderley Park, prior to relocation in the future to a new, state-of-the-art R&D Centre in Cambridge, UK. These roles provide an exciting opportunity to join HTS, the only department within our world-leading pharmaceutical business that focuses unequivocally on Hit identification. You will get unrivalled exposure to the drug discovery process, working on multiple projects across therapeutic areas in a culture that fosters collaboration.

Our HTS Centre aids the definition and delivers bespoke screening cascades to support discovery programmes, applies cutting edge assay technologies to generate high-quality screening data and delivers robust data packages to pursue tractable hit series. Whether you’re looking to share your experience, or get the training to build it, you could be part of a team that uses world-class science and technology to deliver the most innovative tools for drug discovery. You will maintain scientific perfection, presenting data to key stakeholders internally and at external conferences in addition to publishing in peer-reviewed journals.

We need candidates who have the relevant knowledge, attention to detail and a passion for science. At AstraZeneca we work together to provide medicines that make a real difference in patient care. If you’re passionate about the possibilities of science to make a difference and ready to discover what you can do – join us.

You will join a team of scientists delivering High Throughput Screens to AstraZeneca drug projects and academic collaborators, improving the delivery of projects in compliance with SHE requirements. You will have a passion for scientific delivery and innovation, developing science and technology strategy and crafting the future of the HTS capability, and building positive relationships with scientific colleagues. You will be a member of the Discovery Sciences organization, working within an outstanding scientific environment to support drug discovery across each of AstraZeneca’s Therapeutic Areas. As part of an HTS team you will be key in delivering biology and technology output. You’ll have every tool to acquire both practical and academic skills and become a true expert in your field.

Essential Requirements

• BSc/MSc/PhD in a relevant biology discipline or equivalent experience
• Flexibility to work at Alderley Park, Cheshire initially and then relocate to Cambridge
• Ability to drive the practical application of new assay approaches to screening and drug discovery science in Hit Discovery
• Familiarity with technology-rich lab environments.
• Excellent team working, communication and networking skills with experience of interacting effectively across interfaces of discipline, culture and expertise.

Desirable Requirements

• Strong understanding of the analysis and interpretation of screening data to understand mechanism of target engagement. Experience of at scale data analysis and statistics
• Experience working in a pharmaceutical or biotech laboratory environment e.g. industrial placement
• Assay Development, cascade design and drug discovery project team experience
• Demonstrable experience in cellular, imaging, biochemical or biophysical screening approaches and ability to troubleshoot screening problems
• Understanding of state-of-the-art assay and automation technology platforms
• Publication record and/or experience of presenting scientific data
• Experience of small molecule screening and/or fragment-based screening.
• Experience of laboratory automation and a keen interest to develop knowledge in this space
• Experience of coordinating SHE activities

How to Apply

Please apply online before midnight on 29th October 2020.

Date Posted

Closing Date

AstraZeneca embraces diversity and equality of opportunity.  We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills.  We believe that the more inclusive we are, the better our work will be.  We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics.  We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.