YOUR TASKS AND RESPONSIBILITIES   Independently conduct scientific projects in the field of lead discovery Design and establish novel and innovative cell biological assays and assay readouts for usage in high throughput screening (HTS) approaches Drive continuous improvement in methodology, scientific processes and existing assay platforms Analyze and interpret results with the focus on identification of novel lead compounds or novel disease relevant targets/cellular pathways and mechanisms Pres...

YOUR TASKS AND RESPONSIBILITIES   Collaborating with Integrated Care (IC) design and evidence generation teams and product owners on product design and development Supporting the development of the digital health modules by exploring and compiling the scientific and medical evidence and literature related to the targeted problem space; this includes defining/documenting patient pathways, signs, symptoms and potentially trackable variables to be considered in the digital module as well as investi...

YOUR TASKS AND RESPONSIBILITIES   Molecular cloning, expression, purification of target proteins for structure determination Analyze protein ligand interaction by using a variety of biophysical techniques to validate and characterize binding Collect data at synchrotron and internal x-ray sources as well as data processing, structure solution and refinement Plan experiments and evaluate, interpret, present and publish scientific results Collaborate in interdisciplinary teams from structural biolo...

YOUR TASKS AND RESPONSIBILITIES   We are advertising a 2-year post-doctorate position as part of the IMI project Resolution. The aim of this project is to discover therapeutic targets among the solute carrier (SLC) group of human membrane transporters. Your role within this project will be to support genetic validation of potential targets and develop a framework that allows for genetic assessment at scale across all SLCs.   In addition to working with the IMI partners, you will be based in the ...

YOUR TASKS AND RESPONSIBILITIES Familiarization with large and high-dimensional longitudinal (time-dependent) data structures, as available via electronic health records Gaining insights into typical research questions of data scientists working in the pharmaceutical industry Development of a robust and generalizable quality control framework of longitudinal data Performance evaluation of different analysis strategies to conduct longitudinal data analysis on real world and simulated datasets (e....

YOUR TASKS AND RESPONSIBILITIES   Leads the Clinical Development (CD) team, a cross functional, multinational team of internal experts, through clinical phase II - III trials and global product registration, as well as supporting product life cycle optimization Sets project-related objectives with Global Project Team (GPT) members In consultation with relevant key disciplines, prepares the Clinical Development Plan (CDP), including an operational plan with high level resource planning (timelines...

IHRE AUFGABEN UND VERANTWORTLICHKEITEN   Klonierung, Expression und Reinigung von Proteinen für die Strukturaufklärung Untersuchung von Protein-Ligand-Bindung mit biophysikalischen Techniken zur Validierung und Charakterisierung der Interaktion Datensammlungen am Synchrotron und an internen Röntgenquellen sowie Datenprozessierung, Strukturaufklärung und Verfeinerung Planung von Experimenten sowie Auswertung und Interpretation wissenschaftlicher Ergebnisse Zusammenarbeit in interdisziplinären Tea...

YOUR TASKS AND RESPONSIBILITIES   Substantially support the development of a sustainable discovery and early development portfolio in the field of ophthalmology in close interaction with other (pre-)clinical functions Contribute to the achievement of yearly research deliverables: Characterization of preclinical candidates and clinical compounds in relevant eye disease models, act as preclinical pharmacology expert in support of Global Project Teams Support pipeline building activities through ev...